: Cancer Articles
Perspective: Revisiting the biological roles of PAI2 (SERPINB2) in cancerTumour expression of the urokinase plasminogen activator correlates with invasive capacity. Consequently, inhibition of this serine protease by physiological inhibitors should decrease invasion and metastasis. However, of the two main urokinase inhibitors, high tumour levels of the type 1 inhibitor actually promote tumour progression, whereas Nature Reviews Cancer, vol. 8 #7, pp535-545 |
Review: Recurrent gene fusions in prostate cancerThe discovery of recurrent gene fusions in a majority of prostate cancers has important clinical and biological implications in the study of common epithelial tumours. Gene fusion and chromosomal rearrangements were previously thought to be primarily the oncogenic mechanism of haematological malignancies and sarcomas. The Nature Reviews Cancer, vol. 8 #7, pp497-511 |
Perspective: Banking on cord blood stem cellsUmbilical cord blood gifted to non-profit public cord blood banks is now routinely used as an alternative source of haematopoietic stem cells for allogeneic transplantation for children and adults with cancer, bone marrow failure syndromes, haemoglobinopathies and many genetic metabolic disorders. Because of the success Nature Reviews Cancer, vol. 8 #7, pp555-563 |
Perspective: Exploring the role of cancer stem cells in radioresistanceRadiobiological research over the past decades has provided evidence that cancer stem cell content and the intrinsic radiosensitivity of cancer stem cells varies between tumours, thereby affecting their radiocurability. Translation of this knowledge into predictive tests for the clinic has so far been hampered by Nature Reviews Cancer, vol. 8 #7, pp545-554 |
Progress: Targeting the oncogene and kinome chaperone CDC37CDC37 is a molecular chaperone that physically stabilizes the catalytic domains found in protein kinases and is therefore a wide-spectrum regulator of protein phosphorylation. It is also an overexpressed oncoprotein that mediates carcinogenesis by stabilizing the compromised structures of mutant and/or overexpressed oncogenic kinases. Recent Nature Reviews Cancer, vol. 8 #7, pp491-495 |
Review: MYB function in normal and cancer cellsThe transcription factor MYB has a key role as a regulator of stem and progenitor cells in the bone marrow, colonic crypts and a neurogenic region of the adult brain. It is in these compartments that a deficit in MYB activity leads to severe or Nature Reviews Cancer, vol. 8 #7, pp523-534 |
Review: Living on a break: cellular senescence as a DNA-damage responseCellular senescence is associated with ageing and cancer in vivo and has a proven tumour-suppressive function. Common to both ageing and cancer is the generation of DNA damage and the engagement of the DNA-damage response pathways. In this Review, the diverse mechanisms that lead Nature Reviews Cancer, vol. 8 #7, pp512-522 |