: Cancer Articles
Perspective: Replication licensing and cancer — a fatal entanglement?Correct regulation of the replication licensing system ensures that chromosomal DNA is precisely duplicated in each cell division cycle. Licensing proteins are inappropriately expressed at an early stage of tumorigenesis in a wide variety of cancers. Here we discuss evidence that misregulation of replication licensing Nature Reviews Cancer, vol. 8 #10, pp799-806 |
Perspective: Bone morphogenetic protein signalling in colorectal cancerMuch of the current understanding of colorectal cancer stems from the study of rare, inherited colorectal cancer syndromes. Mutations in the bone morphogenetic protein (BMP) pathway have been found in juvenile polyposis, an inherited polyposis syndrome that predisposes to colorectal cancer. The hamartomas that develop Nature Reviews Cancer, vol. 8 #10, pp806-812 |
Perspective: Can genes for mammographic density inform cancer aetiology?Mammographic density (MD) reflects variations in fat, stromal and epithelial tissues that are thought to be regulated by several genes. High MD is an established risk factor for breast cancer; therefore, genes that regulate MD may indirectly influence breast cancer. These genes might also be Nature Reviews Cancer, vol. 8 #10, pp812-823 |
Review: Cancer stem cells in solid tumours: accumulating evidence and unresolved questionsSolid tumours are an enormous cancer burden and a major therapeutic challenge. The cancer stem cell (CSC) hypothesis provides an attractive cellular mechanism to account for the therapeutic refractoriness and dormant behaviour exhibited by many of these tumours. There is increasing evidence that diverse solid Nature Reviews Cancer, vol. 8 #10, pp755-768 |
Review: The role of the RB tumour suppressor pathway in oxidative stress responses in the haematopoietic systemExposure to pro-oxidants and defects in the repair of oxidative base damage are associated with disease and ageing and also contribute to the development of anaemia, bone marrow failure and haematopoietic malignancies. This Review assesses emerging data indicative of a specific role for the RB Nature Reviews Cancer, vol. 8 #10, pp769-781 |
Review: The TRAIL apoptotic pathway in cancer onset, progression and therapyTriggering of tumour cell apoptosis is the foundation of many cancer therapies. Death receptors of the tumour necrosis factor (TNF) superfamily have been largely characterized, as have the signals that are generated when these receptors are activated. TNF-related apoptosis-inducing ligand (TRAIL) receptors (TRAILR1 and TRAILR2) Nature Reviews Cancer, vol. 8 #10, pp782-798 |
Review: Basal cell carcinomas: attack of the hedgehogBasal cell carcinomas (BCCs) were essentially a molecular 'black box' until some 12 years ago, when identification of a genetic flaw in a rare subset of patients who have a great propensity to develop BCCs pointed to aberrant Hedgehog signalling as the pivotal defect leading Nature Reviews Cancer, vol. 8 #10, pp743-754 |