: Immunology Articles
Editorial: Don't stop me nowDespite pessimism in the media surrounding the recent failure of the Merck HIV vaccine, researchers should applaud their achievements and step up to the challenges ahead. Nature Immunology, vol. 9 #8, pp821-821 |
News and Views: Distinct functions for HS1 in chemosensory versus adhesive signalingHost immunity requires cytotoxic lymphocytes that are able to move toward their targets but are also able to stop after identifying target cells and then establish stable cell-cell contact. A new study shows that separate phosphorylation sites in HS1, an actin cytoskeleton–remodeling factor, can regulate both processes. Nature Immunology, vol. 9 #8, pp833-834 |
News and Views: Arrestin NK cell cytotoxicityA key regulator of the balance of signals that activate effector mechanisms versus those that restrain them, β-arrestin 2 mediates the inhibition of natural killer cell cytotoxicity. Nature Immunology, vol. 9 #8, pp835-836 |
News and Views: Cat and mouseNew findings show that ERAAP, an endoplasmic reticulum aminopeptidase involved in antigen processing, helps mice survive encounters with a feline-derived parasite. Nature Immunology, vol. 9 #8, pp829-830 |
News and Views: A 'fly-by' killing with a primordial cellular weaponAutophagy has been suggested—on the basis of in vitro studies—to be involved in defense against bacterial challenge. A study in drosophila now shows the importance of autophagy in vivo and links a pattern recognition receptor to the autophagy pathway. Nature Immunology, vol. 9 #8, pp827-829 |
News and Views: NLRs and the dangers of pollution and agingThe production of inflammatory interleukin 1β after uptake of silica crystals and alum salt or amyloid-β occurs by a process that involves lysosomal destabilization and release of cathepsin B that activates the NLRP3 inflammasome. Nature Immunology, vol. 9 #8, pp831-833 |