: Microbiology Articles
Review: The RSK family of kinases: emerging roles in cellular signallingThe 90 kDa ribosomal S6 kinase (RSK) family of proteins is a group of highly conserved Ser/Thr kinases that regulate diverse cellular processes, such as cell growth, cell motility, cell survival and cell proliferation. RSKs are downstream effectors of the Ras–extracellular signal-regulated kinase (ERK)/mitogen-activated protein Nature Reviews Molecular Cell Biology, vol. 9 #10, pp747-758 |
Review: Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancerFirst described over 80 years ago, ataxia-telangiectasia (A-T) was defined as a clinical entity 50 years ago. Although not encountered by most clinicians, it is a paradigm for cancer predisposition and neurodegenerative disorders and has a central role in our understanding of the DNA-damage response, Nature Reviews Molecular Cell Biology, vol. 9 #10, pp759-769 |
Review: Phagosome maturation: going through the acid testPhagosome maturation is the process by which internalized particles (such as bacteria and apoptotic cells) are trafficked into a series of increasingly acidified membrane-bound structures, leading to particle degradation. The characterization of the phagosomal proteome and studies in model organisms and mammals have led to Nature Reviews Molecular Cell Biology, vol. 9 #10, pp781-795 |
Review: The cell biology of cell-in-cell structuresFor decades, authors have described unusual cell structures, referred to as cell-in-cell structures, in which whole cells are found in the cytoplasm of other cells. One well-characterized process that results in the transient appearance of such structures is the engulfment of apoptotic cells by phagocytosis. Nature Reviews Molecular Cell Biology, vol. 9 #10, pp796-809 |
Perspective: Is there a code embedded in proteins that is based on post-translational modifications?Covalent post-translational modifications (PTMs) provide vast indexing potential and expanded protein use. The 'histone code' hypothesis has inspired rapid advances throughout chromatin biology, and has recently been tapped for its relevance to non-histone proteins. Comprehensive analyses suggest that rather than constituting a general code, the Nature Reviews Molecular Cell Biology, vol. 9 #10, pp815-820 |
Review: Modelling and analysis of gene regulatory networksGene regulatory networks have an important role in every process of life, including cell differentiation, metabolism, the cell cycle and signal transduction. By understanding the dynamics of these networks we can shed light on the mechanisms of diseases that occur when these cellular processes are Nature Reviews Molecular Cell Biology, vol. 9 #10, pp770-780 |
Perspective: Transcription-independent functions of MYC: regulation of translation and DNA replicationMYC is a potent oncogene that drives unrestrained cell growth and proliferation. Shortly after its discovery as an oncogene, the MYC protein was recognized as a sequence-specific transcription factor. Since that time, MYC oncogene research has focused on the mechanism of MYC-induced transcription Nature Reviews Molecular Cell Biology, vol. 9 #10, pp810-815 |