: Methods Articles
Editorial: Going for algorithm goldThe use of organized competition to evaluate algorithm performance would be very beneficial for small communities, not just large ones. Nature Methods, vol. 5 #8, pp659-659 |
Research Highlights: Induced pluripotency: is there a silver bullet?Ongoing efforts show promise in replacing reprogramming factors with small molecules for making induced pluripotent stem cells. Nature Methods, vol. 5 #8, pp661-661 |
Research Highlights: A time stamp for proteinsA new protein tag simplifies labeling and visualization of newly synthesized target proteins in tissue and whole animals. Nature Methods, vol. 5 #8, pp662-663 |
Research Highlights: Talk among histonesUsing chemically assembled ubiquitylated histone H2B, researchers demonstrate that direct cross-talk results in methylation of a lysine on another histone. Nature Methods, vol. 5 #8, pp662-663 |
Research Highlights: Surviving the gas phaseResearchers demonstrate a method for observing intact membrane protein complexes by mass spectrometry. Nature Methods, vol. 5 #8, pp664-664 |
Research Highlights: Unraveling the nucleosomeNext-generation sequencing–based studies locate nucleosomes at high resolution throughout several genomes. Nature Methods, vol. 5 #8, pp666-666 |
Research Highlights: Multiplexing MRIBy engineering magnetic microstructures, researchers demonstrate the potential for multiplexed MRI. Nature Methods, vol. 5 #8, pp668-668 |
News and Views: Single-particle tracking: connecting the dotsAlgorithms for analyzing single-particle tracking images to obtain the paths of individual particles are challenged by high-density data. Improvements in algorithms help to overcome these limitations. Nature Methods, vol. 5 #8, pp671-672 |
Brief Communication: Alta-Cyclic: a self-optimizing base caller for next-generation sequencingA new base caller for the Illumina Genome Analyzer uses machine learning to compensate for noise factors and improves accuracy for up to 78-base-pair sequencing reads. Nature Methods, vol. 5 #8, pp679-682 |
Brief Communication: Improving membrane voltage measurements using FRET with new fluorescent proteinsDesigning fluorescent protein-based sensors that display large changes in fluorescence resonance energy transfer (FRET) is challenging. Redesign of a FRET-based voltage sensor using new fluorescent proteins increased the sensor response to changes in membrane voltage and measurements at warmer temperatures displayed faster kinetics comparable to action potentials. Nature Methods, vol. 5 #8, pp683-685 |