: Drug Discovery Articles
Perspective: Economic issues with follow-on protein productsThe economic effects of the possible introduction of 'follow-on' protein products have been the subject of recent debate. Here, we aim to explore the economic issues surrounding this debate using three measures: total sales, product complexity and patent expiry. Our analysis shows that the sales Nature Reviews Drug Discovery, vol. 7 #9, pp733-737 |
Perspective: Perspectives on NMR in drug discovery: a technique comes of ageIn the past decade, the potential of harnessing the ability of nuclear magnetic resonance (NMR) spectroscopy to monitor intermolecular interactions as a tool for drug discovery has been increasingly appreciated in academia and industry. In this Perspective, we highlight some of the major applications of Nature Reviews Drug Discovery, vol. 7 #9, pp738-745 |
Review: Nanoparticle therapeutics: an emerging treatment modality for cancerNanoparticles — particles in the size range 1–100 nm — are emerging as a class of therapeutics for cancer. Early clinical results suggest that nanoparticle therapeutics can show enhanced efficacy, while simultaneously reducing side effects, owing to properties such as more targeted localization in tumours Nature Reviews Drug Discovery, vol. 7 #9, pp771-782 |
Review: Adenosine receptors: therapeutic aspects for inflammatory and immune diseasesAdenosine is a key endogenous molecule that regulates tissue function by activating four G-protein-coupled adenosine receptors: A1, A2A, A2B and A3. Cells of the immune system express these receptors and are responsive to the modulatory effects of Nature Reviews Drug Discovery, vol. 7 #9, pp759-770 |
Review: Targeting of tetraspanin proteins — potential benefits and strategiesThe tetraspanin transmembrane proteins have emerged as key players in malignancy, the immune system, during fertilization and infectious disease processes. Tetraspanins engage in a wide range of specific molecular interactions, occurring through the formation of tetraspanin-enriched microdomains (TEMs). TEMs therefore serve as a starting point Nature Reviews Drug Discovery, vol. 7 #9, pp747-758 |