: Drug Discovery Articles
Perspective: Balancing early market access to new drugs with the need for benefit/risk data: a mounting dilemmaDrug regulatory agencies are increasingly pressed by the challenge of finding the appropriate balance between the need for rapid access to new drugs and the need to ensure comprehensive data on their benefits and risks. This dilemma is not new, but has been made more Nature Reviews Drug Discovery, vol. 7 #10, pp818-826 |
Perspective: Pharmacogenetics in drug discovery and development: a translational perspectiveThe ability to predict a patient's drug response on the basis of their genetic information is expected to decrease attrition during the development of new, innovative drugs, and reduce adverse events by being able to predict individual patients at risk. Most pharmacogenetic investigations have focused Nature Reviews Drug Discovery, vol. 7 #10, pp807-817 |
Review: The IL-33/ST2 pathway: therapeutic target and novel biomarkerFor many years, the interleukin-1 receptor family member ST2 was an orphan receptor that was studied in the context of inflammatory and autoimmune disease. However, in 2005, a new cytokine — interleukin-33 (IL-33) — was identified as a functional ligand for ST2. IL-33/ST2 signalling is Nature Reviews Drug Discovery, vol. 7 #10, pp827-840 |
Review: Sirtuins — novel therapeutic targets to treat age-associated diseasesSirtuins post-translationally modulate the function of many cellular proteins that undergo reversible acetylation–deacetylation cycles, affecting physiological responses that have implications for treating diseases of ageing. Potent small-molecule modulators of sirtuins have shown efficacy in preclinical models of metabolic, neurodegenerative and inflammatory diseases, and so hold Nature Reviews Drug Discovery, vol. 7 #10, pp841-853 |
Review: Therapeutic application of histone deacetylase inhibitors for central nervous system disordersHistone deacetylases (HDACs) — enzymes that affect the acetylation status of histones and other important cellular proteins — have been recognized as potentially useful therapeutic targets for a broad range of human disorders. Pharmacological manipulations using small-molecule HDAC inhibitors — which may restore transcriptional balance Nature Reviews Drug Discovery, vol. 7 #10, pp854-868 |