Kazutoshi Mori, Professor at Kyoto University, shares the 2014 Lasker Basic Medical Research Award with Peter Walter, Professor at the University of California, San Francisco. Walter and Mori are honored for their work identifying core components of the unfolded protein response (UPR). Mori made his first major discovery in this area—identification of the IRE1 component of the UPR—in 1993, while he was a postdoctoral fellow at the University of Texas Southwestern Medical Center.