To create a strong biosafety culture, information on mishaps involving deadly pathogens must be reported and shared fully and transparently.
doi: 10.1038/511507a
Delays in approving genetically engineered salmon may be a taste of worse to come.
doi: 10.1038/511507b
Experts call for a stronger safety culture at secure sites after incidents involving anthrax and flu in a US laboratory.
doi: 10.1038/511515a
Sensors in borehole at New Zealand seismic fault will peek under the surface of impending rupture.
doi: 10.1038/511516a
Mycoplasma infestations are widespread and costing laboratories millions of dollars in lost research.
doi: 10.1038/511518a
US drug regulator weighs up merits of disclosing preliminary results.
doi: 10.1038/511519a
Logistics and lack of funds keep experimental drugs and vaccines from being used in Africa outbreak.
doi: 10.1038/511520a
古いダムの撤去によって自由な流れのよみがえった米国の川に、さまざまな生物種が戻ってきている。
doi: 10.1038/511521a
血中のDNAを調べる血液生検が、がんの治療方針の手引きになるかもしれない。
doi: 10.1038/511524a
3400万年ほど前、南極では氷床が急速に発達した。モデル研究によって、この氷河発達の根本的原因は大気中の二酸化炭素濃度の低下であることが示された。
doi: 10.1038/511536a
サルを使った研究で、タンパク質であるインターフェロンの投与はサル免疫不全ウイルスへの感染を防止するが、投与を長期間続けると感染の慢性段階が悪化することが明らかになった。
doi: 10.1038/nature13517
超伝導量子系が2つの選ばれた初期状態と終状態の間で発展する際のランダムなトラジェクトリーを継続的に追跡した実験により、この系の最も確率の高い経路が決定された。
doi: 10.1038/511538a
ヒトの卵、精子および初期胚についての2つの研究から、遺伝子転写に影響する分子レベルの修飾であるDNAメチル化が、受精後に大幅に消失することが明らかになった。
doi: 10.1038/nature13648
マラリア原虫のタンパク質を感染宿主細胞の細胞質内に運び出す際には、タンパク質複合体のPTEXが必要であることが2つの研究によって実証され、このようなタンパク質搬出がマラリア原虫の生存に不可欠であることが示された。
doi: 10.1038/nature13646
An integrated transcriptome, genome, methylome and proteome analysis of over 200 lung adenocarcinomas reveals high rates of somatic mutations, 18 statistically significantly mutated genes including RIT1 and MGA, splicing changes, and alterations in MAPK and PI(3)K pathway activity.
doi: 10.1038/nature13385
Topoisomerase II mediates meiotic crossover interference by adjusting the protein/DNA meshwork of chromosome axes.
doi: 10.1038/nature13442
An X-ray structure is presented for metabotropic glutamate receptor 5, a class C G-protein-coupled glutamate receptor linked to fragile X syndrome and neurological disorders; this study provides insights into the protein’s mechanism of action.
doi: 10.1038/nature13396
Measurements of the velocities of pairs of diametrically opposed satellite galaxies of host galaxies in the local Universe show that satellite pairs out to a distance of 150 kiloparsecs from their hosts are anti-correlated in their velocities and that galaxies in the larger-scale environment are strongly clumped along the axis joining the inner satellite pair.
doi: 10.1038/nature13481
Observations show that one or both of the protoplanetary disks in the young binary system HK Tauri are significantly inclined to the binary orbital plane, demonstrating that the necessary conditions exist for the misalignment-driven mechanisms thought to produce the unusual orbits of some extrasolar planets.
doi: 10.1038/nature13521
Reconstruction of the quantum trajectories of a superconducting circuit that evolves under the competing influences of continuous weak measurement and Rabi drive makes it possible to deduce the most probable path through quantum state space.
doi: 10.1038/nature13559
A climate model is used to show that the growth of the Antarctic ice sheet at about 34 Myr ago drove changes in ocean circulation, but the opening of ocean gateways had relatively little impact.
doi: 10.1038/nature13597
A new bombardment model of the early Earth, calibrated with existing lunar and terrestrial data, shows that the Earth’s surface would have been widely reprocessed by impacts through mixing and burial by impact-generated melt; the model may also explain the age distribution of ancient zircons and the absence of early terrestrial rocks.
doi: 10.1038/nature13539
Large annual variation in the stimulation of above-ground biomass by elevated carbon dioxide in a mixed C3/C4 temperate grassland can be predicted accurately using seasonal rainfall totals.
doi: 10.1038/nature13281
This paper demonstrates that a protein complex known as PTEX translocates all malaria parasite proteins destined for export into the cytosol of their host red blood cell.
doi: 10.1038/nature13555
Plasmodium parasites, the causative agent of malaria, infect and remodel red blood cells by exporting hundreds of proteins into the red blood cell cytosol, a topological conundrum given that the parasite resides in a compartment known as the parasitophorous vacuole; here a dihydrofolate-reductase-based destabilization domain approach is used to inactivate HSP101, part of the Plasmodium translocon of exported proteins, and to demonstrate that it is required for the secretion of all classes of exported Plasmodium proteins.
doi: 10.1038/nature13574
Different amounts of excitation received by different pyramidal cells of primary visual cortex are matched by proportional amounts of inhibition.
doi: 10.1038/nature13321
The timing of type I interferon signalling determines the disease course of SIV infection.
doi: 10.1038/nature13554
Base-resolution maps of DNA methylation in human gametes and early embryos offer novel insights into human methylation dynamics and the functional relationship between DNA methylation and gene expression.
doi: 10.1038/nature13544
Genome-scale DNA methylation maps over early human embryogenesis and embryonic stem cell derivation provide insights into shared and unique modes of regulation when compared to the mouse model, including relationships to gene expression, transposable element activity, and maternal-specific methylation.
doi: 10.1038/nature13581
Here, a covalent inhibitor targeting cyclin-dependent kinase 7 (CDK7) demonstrates in vitro and in vivo efficacy against T-cell acute lymphoblastic leukaemia by downregulating oncogenic transcriptional programs.
doi: 10.1038/nature13393
