米国トランプ大統領は、就任100日を迎えてもなお主要ポストの指名をしておらず、政権の混迷が見てとれる。
Trump’s empty chairs rob science of a voice in government p.5
Delay in making presidential appointments harms research and the broader public.
doi: 10.1038/545005a
Delay in making presidential appointments harms research and the broader public.
doi: 10.1038/545005a
Funders should force universities to support laboratories’ research health.
doi: 10.1038/545005b
The apparent slowdown in global warming has provided a spur for better understanding of the underlying processes.
doi: 10.1038/545006a
Alfredo Fusco denies claims that his research lab hired a photo studio to manipulate images.
doi: 10.1038/545013a
Ancient rock art research could piece together how the peoples who lived in the region some 5,700 years ago interacted.
doi: 10.1038/545014a
Scientists offer more detail on flagship programme to harness quantum effects in devices.
doi: 10.1038/545016a
Ketamine can ease depression in hours, but researchers might have misjudged how it works.
doi: 10.1038/545017a
Money will be used to develop open-source platform and help put articles in web-friendly formats.
doi: 10.1038/nature.2017.21894
ある実験手法によって、神経系と免疫系がつながっていることが明らかになったが、これは大きな変革の始まりになるだろうか。
doi: 10.1038/545020a
ポリネシアのマンガイア島における入植のタイムラインが修正され、この島の入植者たちの優れた復元力が明らかになった。彼らは、いくつかの大胆な対策によって環境危機を乗り越え、社会を維持していたのである。
doi: 10.1038/545032a
ポリQ反復配列と呼ばれる伸張部を含む変異タンパク質は、誤って折りたたまれたり、神経変性につながる凝集体を形成したりすることがある。今回、ポリQを含むタンパク質の一部は、誤って折りたたまれたタンパク質を劣化させる過程を調節していることが明らかになった。
doi: 10.1038/nature22489
アルケンと呼ばれる炭化水素は、異性体の混合物として石油から分離されるため、合成用の試薬として使うのが難しいことが多い。今回、移動するニッケル原子が関与する反応から、この問題を解決できる可能性のある方法が得られた。
doi: 10.1038/545035a
今回、分子シャペロンタンパク質HSP90に関する2件の研究で、遺伝的状況や環境的状況によってこの分子の複雑な形質がどのように形作られるかが明らかになった。この結果から、個別化医療の課題が浮き彫りになった。
doi: 10.1038/nature22487
短期的な気候傾向は、定義、データ、評価に敏感である。こうした敏感さが、いわゆる地球温暖化の停滞の根底にあり、実際に停滞があったという主張を裏付けるには、意味のある明確な定義が必要であることを浮き彫りにしている。
doi: 10.1038/545037a
今回、2件の研究によって、ヒトの脳構造によく似た3D培養組織を成長させ分析する最先端技術が統合され、どのようにして脳領域が相互作用しニューロンが成熟するかが調べられるようになった。
doi: 10.1038/545039a
Apparently contradictory conclusions regarding the ‘global warming hiatus’ are reconciled, strengthening the current scientific understanding that long-term global warming is extremely likely to be of anthropogenic origin.
doi: 10.1038/nature22315
Apparently contradictory conclusions regarding the ‘global warming hiatus’ are reconciled, strengthening the current scientific understanding that long-term global warming is extremely likely to be of anthropogenic origin.
doi: 10.1038/nature22047
Human pluripotent stem cells were used to develop dorsal and ventral forebrain 3D spheroids, which can be assembled to study interneuron migration and to derive a functionally integrated forebrain system with cortical interneurons and glutamatergic neurons.
doi: 10.1038/nature22330
The clinical benefit of anti-PD-1 antibody treatment is dependent on the extent to which exhausted CD8 T cells are reinvigorated in relation to the tumour burden of the patient.
doi: 10.1038/nature22079
Multiple crystallographic structures of a concentrative nucleoside transporter show how it uses an ‘elevator’ mechanism to move its transport domain across the membrane.
doi: 10.1038/nature22057
In a quantum dot in the Kondo regime, electrical charges are effectively frozen, but the quantum dot remains electrically conducting owing to strong electron–electron correlations.
doi: 10.1038/nature21704
Quasiparticles in strongly interacting fractional quantum Hall systems carry heat according to the same quantization of thermal conductance as for particles in non-interacting systems.
doi: 10.1038/nature22052
Combining the benefits of nanocrystals with those of amorphous metallic glasses leads to a dual-phase material—comprising sub-10-nanometre-sized nanocrystalline grains embedded in amorphous glassy shells—that exhibits a strength approaching the ideal theoretical limit.
doi: 10.1038/nature21691
A nickel catalyst that promotes carboxylation of halogenated hydrocarbons at remote aliphatic sites with carbon dioxide via tunable and controllable chain-walking is described.
doi: 10.1038/nature22316
Tokummia katalepsis from the Burgess Shale had a pair of mandibles and maxilliped claws, showing that large bivalved arthropods from the Cambrian period are forerunners of myriapods and pancrustaceans, thereby providing a basis for the origin of the hyperdiverse mandibulate body plan.
doi: 10.1038/nature22080
Conditional deletion of the mitochondrial Na+/Ca2+ exchanger NCLX in adult mouse hearts causes sudden death due to mitochondrial calcium overload, whereas its overexpression limits cell death elicited by ischaemia reperfusion injury and heart failure.
doi: 10.1038/nature22082
Interferon-γ acts on tumour endothelial cells to drive vascular regression, inducing ischaemia that leads to tumour collapse.
doi: 10.1038/nature22311
Under physiological forces, resulting from cytokinesis, the mechanosensitivity of adherens junction arises from a local decrease in E-cadherin concentration and results in actomyosin flows.
doi: 10.1038/nature22041
The polyglutamine domain in ataxin 3, which is expanded in spinocerebellar ataxia type 3, allows normal ataxin 3 to interact with and deubiquitinate beclin 1 and thereby to promote autophagy.
doi: 10.1038/nature22078
Crystal structures of protease-activated receptor 2 (PAR2) in complex with two different antagonist ligands and with a blocking antibody reveal binding sites that are distinct from those found on PAR1, offering new leads for structure-based drug design.
doi: 10.1038/nature22309
