研究用原子炉JRR-3の運転再開の遅れが、日本の原子力科学を危うくしている。
Bureaucratic drag dents Japan’s nuclear science p.147
Japan needs a better way to assess whether research reactors are safe to re-open.
doi: 10.1038/d41586-017-08464-2
Japan needs a better way to assess whether research reactors are safe to re-open.
doi: 10.1038/d41586-017-08464-2
Moves to create a multi-speed Internet could push science into the slow lane.
doi: 10.1038/d41586-017-07842-0
To make progress on the grand challenges, authors, reviewers and editors must take the time to respect each others’ expertise and blind spots.
doi: 10.1038/d41586-017-08465-1
Lawsuit alleges that the institution mishandled complaints about cognitive scientist Florian Jaeger.
doi: 10.1038/d41586-017-08235-z
Geneticists analyse DNA from preserved pup, more than 80 years after the last of its kind died.
doi: 10.1038/d41586-017-08368-1
Worries over the cost of an education spill over into protests.
doi: 10.1038/d41586-017-07879-1
Large study suggests acupuncture could help women stick with unpleasant cancer treatments.
doi: 10.1038/d41586-017-08309-y
Government researcher Ricardo Villalba stands accused of shaping a study to benefit mining interests.
doi: 10.1038/d41586-017-08236-y
Natureは、出版後に1回も引用されることない論文がいったいどのくらいあって、その背景にはどのようなことがあるのかを調べた。
doi: 10.1038/d41586-017-08404-0
多能性幹細胞は、全ての体細胞種を生み出す準備ができると、哺乳類の胎児が成長する羊膜腔の形成を始める。この遷移を制御するチェックポイントが、今回特定された。
doi: 10.1038/d41586-017-07436-w
白色矮星と呼ばれる密度の高い星の残存物は、連星系によく見られる。今回、衛星観測によって、白色矮星が伴星から物質を引き出すこれまで知られていなかった機構が示唆された。
doi: 10.1038/d41586-017-08286-2
正常な脳機能に関与する脂肪酸の代謝によって形成される19,20-ジヒドロキシドコサペンタエン酸分子が、マウスモデルで糖尿病に関連する失明の進行を促進することが、今回分かった。
doi: 10.1038/d41586-017-07678-8
進化的に保存されたRNAポリメラーゼIII酵素は、タンパク質合成や細胞の成長を駆動する要因である。今回、この必須酵素を部分的に抑制すると、酵母、線虫、ハエの寿命が延びることが分かった。
doi: 10.1038/d41586-017-07435-x
地質記録から、オーロラ地域の南極氷床が、大気が暖かかった過去の複数の期間に対照的な応答をしていたことが明らかになった。この知見は、現在の温暖化に対する氷床の応答の予測に役立つ可能性がある。
doi: 10.1038/d41586-017-08285-3
宿主細胞の代謝の操作は、ウイルスの複製サイクルに不可欠な側面である。今回、ウイルスによる細胞の長鎖ノンコーディングRNAの吸収が、この過程の重要なステップであることが分かった。
doi: 10.1038/d41586-017-07692-w
Amyloid-β peptide proteopathies disrupt mitochondria, and restoring mitochondrial proteostasis reduces protein aggregation in animal models of amyloid-β disease.
doi: 10.1038/nature25143
Amyloid-β peptide proteopathies disrupt mitochondria, and restoring mitochondrial proteostasis reduces protein aggregation in animal models of amyloid-β disease.
doi: 10.1038/nature25016
The structure of the Ca2+-activated, non-selective ion channel TRPM4 bound to the agonist Ca2+ and a modulator decavanadate, solved using electron cryo-microscopy.
doi: 10.1038/nature24674
Electron cryo-microscopy structures of mouse TRPM4, a calcium-activated, non-selective cation channel, in the apo and ATP-bound states.
doi: 10.1038/nature24997
A weak magnetic field regulates magnetically gated accretion of gas from a companion star onto the white dwarf in the binary system MV Lyrae, previously labelled as a ‘non-magnetic’ system.
doi: 10.1038/nature24653
Miniature hydrogel compartments in scalable stacked and folded geometries were used to prepare a contact-activated artificial electric organ.
doi: 10.1038/nature24670
The formation of cellular adhesion complexes is important in normal and pathological cell activity, and is determined by the force imposed by the combined effect of the distribution of extracellular matrix molecules and substrate rigidity.
doi: 10.1038/nature24662
Geophysical and geological data reveal increased ice-sheet variability and surface meltwater—possibly analogous to future conditions—offshore of the Aurora subglacial basin of East Antarctica during warm climate intervals of the past 50 million years.
doi: 10.1038/nature25026
Methane fluxes from the stems of Amazonian floodplain trees indicate that the escape of soil gas through wetland trees is the dominant source of methane emissions in the Amazon basin.
doi: 10.1038/nature24639
Measurements of the composition-dependent viscosity of rhyolitic magma reveal a tipping point that changes the physical properties of the melt and controls the transition between effusive and explosive eruptions.
doi: 10.1038/nature24488
Exit of epiblasts from an unrestricted naive pluripotent state is required for epithelialization and generation of the pro-amniotic cavity in mouse embryos and for amniotic cavity formation in human embryos and human embryonic stem cells.
doi: 10.1038/nature24675
Triangulation of microbe–phenotype relationships is an effective method for reducing the noise inherent in microbiota studies and enabling identification of causal microbes of disease, which may be applicable to human microbiome studies.
doi: 10.1038/nature25019
A product of the soluble epoxide hydrolase enzyme, 19,20-dihydroxydocosapentaenoic acid (19,20-DHDP), is implicated in the pathogenesis of diabetic retinopathy; levels of 19,20-DHDP increase in the retinas of mice and humans with diabetes, and inhibition of its production can rescue vascular abnormalities in a mouse model of the disease.
doi: 10.1038/nature25013
The transcription factor Runx3 is identified as a central regulator of the development of tissue-resident memory CD8+ T cells, providing insights into the signals that promote T cell residency in non-lymphoid tissues and tumours.
doi: 10.1038/nature24993
The transmembrane domain of NOTCH1 plays a key role in the assembly of adherens junctions and the non-transcriptional regulation of vascular permeability that links transcriptional programs with adhesive and cytoskeletal remodelling.
doi: 10.1038/nature24998
RNA polymerase III is a key evolutionarily conserved regulator of longevity that may have potential as a therapeutic target for age-related conditions.
doi: 10.1038/nature25007
A new mechanism of pre-mRNA splicing regulation is revealed that is mediated by piRNA pathway components and is dependent on heterochromatin histone modifications.
doi: 10.1038/nature25018
The histone acetyl transferase KAT2A (also known as GCN5) can also catalyse histone succinylation, with the α-KGDH complex providing a local source of succinyl-CoA.
doi: 10.1038/nature25003
