China and other countries should look again at how they pay bonuses and allocate grants that are based on individual research papers.
doi: 10.1038/547137a
In sharp contrast to President Trump, Brenda Fitzgerald has put maternal and child health at the heart of her policies.
doi: 10.1038/547137b
Interactions between humans and robots may eventually include sex.
doi: 10.1038/547138a
Pared-back staff struggles to continue cybersecurity, climate-change and science-education efforts without direction from the Trump administration.
doi: 10.1038/547145a
Artificial soils that mimic the surfaces of the Moon, Mars and asteroids are hard to make — and often miss the mark.
doi: 10.1038/nature.2017.22228
The technique could be used on everything from flowers to cells to examine the factors that influence the shapes of plant parts.
doi: 10.1038/nature.2017.22230
Physicists find ways to make LIGO and other gravitational-wave detectors even more sensitive.
doi: 10.1038/547148a
Clutch of DNA analyses show that ancient humans moved around on the continent far more than has been appreciated.
doi: 10.1038/nature.2017.22272
栄養不良、不十分な衛生環境、ネグレクトなどが、子どもの成長や神経の発達に与える影響を調べようと、バングラデシュで前例のない脳画像化研究が行われている。
doi: 10.1038/547150a
位置センサー、速度センサー、加速度センサーの性能は、究極的には量子物理学によって制約される。こうした制約を回避するハイブリッド量子系によって、センサー技術が改善される可能性がある。
doi: 10.1038/547164a
免疫系のT細胞は腫瘍を破壊できるが、その活性化効率は低い場合がある。今回、腫瘍の変異を利用するワクチンによって、腫瘍に対するロバストなT細胞応答が引き出された。これは臨床的に有益である可能性がある。
doi: 10.1038/nature23093
微量元素は、自然の過程や人間の活動によって植物中に濃縮される。今回、北極のツンドラ植生を分析して、植物による大気からの微量金属の吸収について新たな知見が得られた。
doi: 10.1038/547167a
HP1タンパク質は、DNAがヘテロクロマチンと呼ばれる抑制構造に圧縮されるのを仲介する。今回、HP1には液体に似た性質があることが分析によって明らかになり、ゲノム構成について新たな見方が得られた。
doi: 10.1038/nature23089
タウタンパク質は、神経変性を伴う人々の脳にもつれと呼ばれる繊維状の異常な凝集体を形成する（神経原繊維変化）。今回、こうした繊維の2つの構造から、アルツハイマー病の理解を深める道が得られた。
doi: 10.1038/nature23094
今回、胆管の内側を覆う細胞集団を分離し拡大するプロトコルが開発され、生物工学的な胆管をin vitroで発生させることが可能になった。そして、こうした胆管をマウスへ移植すると、天然の胆管を置き換えることができた。
doi: 10.1038/547171a
Results of fine-mapping 94 inflammatory bowel disease loci using high-density genotyping in 67,852 individuals and several new fine-mapping methods.
doi: 10.1038/nature22969
The extracellular matrix protein agrin promotes cardiac regeneration in adult mice after myocardial infarction; it modulates cardiac differentiation and proliferation by interacting with the dystrophin–glycoprotein complex, Yap and ERK-mediated signalling.
doi: 10.1038/nature22978
High-resolution structures of tau filaments shed light on the ultrastructure of neurofibrillary lesions in Alzheimer’s disease.
doi: 10.1038/nature23002
By coupling a mechanical object to an ensemble of atomic spins with negative effective mass, the object’s position can be measured without the usual quantum back-action perturbation of its momentum.
doi: 10.1038/nature22980
Non-symmetric internal alkenes are selectively converted into allylic functionalized products with high stereoselectivity and regioselectivity.
doi: 10.1038/nature22805
A two-year study of mercury deposition in the Arctic finds that the main source of mercury is gaseous elemental mercury, which is deposited throughout the year and leads to very high soil mercury levels.
doi: 10.1038/nature22997
The pyrite-type high-pressure form of FeOOH is predicted from first principles, and found experimentally to be stable under the conditions at the base of the mantle, with implications for transport of water within Earth’s deep interior.
doi: 10.1038/nature22823
In contrast to the prevailing belief that the gut begins with the mouth and continues backwards from there, this work shows that substantial areas of the faces of ray-finned fishes originate from the pre-oral gut or endoderm.
doi: 10.1038/nature23008
Malaria parasites use a sensing mechanism to moderate their growth in response to the nutrient content of their host.
doi: 10.1038/nature23009
The results of a phase I trial assessing a personal neoantigen multi-peptide vaccine in patients with melanoma, showing feasibility, safety, and immunogenicity.
doi: 10.1038/nature22991
The authors report the first-in-human application of personalized neo-antigen RNA vaccines in patients with melanoma.
doi: 10.1038/nature23003
After injury in the heart, postnatal mouse hearts deficient in the Hippo pathway show efficient repair, and in the hearts of Mdx mice (a model of Duchenne muscular dystrophy) Hippo deficiency protects against overload-induced heart failure.
doi: 10.1038/nature22979
A low-input Hi-C method is used to show that chromatin organization is markedly relaxed in pre-implantation mouse embryos after fertilization and that the subsequent maturation of 3D chromatin architecture is surprisingly slow.
doi: 10.1038/nature23263
Phosphorylation or DNA binding promotes the physical partitioning of HP1α out of a soluble aqueous phase into droplets, suggesting that the repressive action of heterochromatin may in part be mediated by the phase separation of HP1.
doi: 10.1038/nature22822
HP1a can nucleate into foci that display liquid properties during the early stages of heterochromatin domain formation in Drosophila embryos, suggesting that the repressive action of heterochromatin may be mediated in part by emergent properties of phase separation.
doi: 10.1038/nature22989
