New tools for exploring the individual characteristics of cells are attracting researchers from other disciplines.
doi: 10.1038/547005a
The Universe’s flash machines have proven their scientific value.
doi: 10.1038/547005b
The geopolitical crisis in the Middle East highlights the vulnerability of supplies of an essential research resource.
doi: 10.1038/547006a
Large projects explore how to integrate data from smart devices with other health metrics.
doi: 10.1038/547013a
Experts say effective response to the outbreak in the Democratic Republic of the Congo helped prevent the virus from spreading.
doi: 10.1038/nature.2017.22227
Conservationists fear trend of selling wild-caught birds will hurt populations.
doi: 10.1038/nature.2017.22198
Researchers braced for shortages as Gulf state forced to close its refineries.
doi: 10.1038/547016a
Influential report suggests simpler, more citizen-friendly system for post-2020 EU research funding.
doi: 10.1038/547017a
生命の最も基本的単位の解析が、より良い治療法や重要な生命過程の手掛かりにつながると、期待が膨らんでいる。
doi: 10.1038/547019a
科学者たちは、胚から成体までの発生を、細胞ごとに捉えてより深く理解しようと懸命に努力している。
doi: 10.1038/547020a
米国ブロード研究所のAviv Regevは、単一細胞をゲノミクス手法を用いて調べ、人体の全細胞をマッピングしようと取り組んでいる。
doi: 10.1038/547024a
DNAは、クロマチンとして細胞内に格納され、折りたたまれて組織化されたドメインを作っている。今回、単一細胞のクロマチン接触状況のマッピングによって、こうしたドメインの細胞分裂時の動的な変化に光が当てられた。
doi: 10.1038/547034a
今回、微小化石によって、1万400〜7500年前に、周極深層水と呼ばれる水塊の湧昇が南極の棚氷を不安定化していたことが示された。この知見は、氷床の後退に関する我々の理解を深める。
doi: 10.1038/547035a
T細胞受容体と、通常は生体内に存在しないペプチド分子との結合が、免疫応答の引き金となることがある。どのペプチドがT細胞と結合するか予測するのは困難だが、それが今回実現された。
doi: 10.1038/nature23091
集積回路には、電子デバイスが1層しかないことが多く、これが集積回路の性能や機能を制限している。複数のデバイス層を合体させた3D集積回路によって、多様な応用が可能になる。
doi: 10.1038/547038a
乳がんゲノム360例の解析によって、遺伝子発現を調節するプロモーターと呼ばれる非コードDNA配列の9つで、がんのドライバー変異が見つかった。この結果は、非コードドライバーが多く存在することを示唆している。
doi: 10.1038/nature23085
大質量星は、対になって連星系をなしていることが多い。今回、観測によって、そうした連星系の星は、これまで考えられていたより互いに離れた場所で生まれたことが明らかになった。これは、星形成に関する息の長い議論に新たな光を当てる。
doi: 10.1038/nature23092
During the early Holocene epoch—and since the 1940s—variations in Southern Hemisphere westerly winds controlled the upwelling of Circumpolar Deep Water and seemingly ice-sheet retreat in West Antarctica.
doi: 10.1038/nature22995
Permanently ice-free areas, home to almost all of Antarctica’s biodiversity, are projected, in the worst case, to expand by over 17,000 km2 as a result of climate change by the end of this century, with potentially deleterious consequences for the continent’s biodiversity.
doi: 10.1038/nature22996
High-depth sequencing of targeted regions in primary breast cancer identifies mutated promoter elements with recurrent mutations at specific and/or nearby bases, suggesting selection of certain non-coding events.
doi: 10.1038/nature22992
Single-cell Hi-C analysis in thousands of mouse embryonic stem cells shows that chromosomal compartments, topological-associated domains and long-range loops all have distinct cell-cycle dynamics.
doi: 10.1038/nature23001
Single-molecule FRET imaging provides insights into the allosteric link between the ligand-binding and G-protein nucleotide-binding pockets of the β2 adrenergic receptor (β2AR) and improved understanding of the G-protein activation mechanism.
doi: 10.1038/nature22354
Multiple nanotechnologies are integrated on a single chip to realize a three-dimensional integrated circuit architecture that combines computing and data storage—a potentially transformative advance in computing.
doi: 10.1038/nature22994
Using a triple catalytic approach, a selective sp 3 C–H alkylation is demonstrated that is applicable in late-stage functionalization of pharmaceutical compounds.
doi: 10.1038/nature22813
GPS measurements are used to investigate the continental rift system of North Island, New Zealand, and to develop a model for short-term deformation involving flexing of an elastic upper crust caused by episodic changes in mantle viscosity and melt fraction.
doi: 10.1038/nature22962
The authors characterize epitope-specific T cell repertoires, identify shared and recognizable features of TCRs, and develop tools to classify antigen specificity on the basis of sequence analysis.
doi: 10.1038/nature22383
The authors devise an algorithm that can cluster T cell receptor (TCR) sequences sharing the same specificity, predict the HLA restriction of these TCR clusters on the basis of subjects’ genotypes and help to identify specific peptide major histocompatibility complex ligands.
doi: 10.1038/nature22976
Chemotherapy drugs can cause pyroptotic cell death by activating caspase-3 to cleave gasdermin E, potentially contributing to their toxicity and adverse effects.
doi: 10.1038/nature22393
Identification of the cell types from which relapse arises in acute myeloid leukaemia, by following leukaemia propagation from patient-derived leukaemia samples.
doi: 10.1038/nature22993
mTOR complex 1 signalling regulates polyamine metabolism and thereby promotes tumorigenesis, through regulation of the stability of a key enzyme, AMD1.
doi: 10.1038/nature22964
RNase III from all three domains of life elicits RNA-targeting antiviral activity that is independent of, and possibly predates, other known eukaryotic antiviral systems.
doi: 10.1038/nature22990
Single-particle electron cryo-microscopy analysis of the mechanotransduction channel NOMPC reveals that it contains a bundle of four helical spring-shaped ankyrin repeat domains that undergo motion, potentially allowing mechanical movement of the cytoskeleton to be coupled to the opening of the channel.
doi: 10.1038/nature22981
