すでに広く利用されている治療法の臨床試験であっても、被験者にはあらゆる危険性を確実に知らせるべきだ。
Subject to question p.377
Even when conducting clinical trials to study widely used therapies, researchers must ensure that they disclose the full risks to patients.
doi: 10.1038/500377a
array:6 [ 14 => NPG_Content_Model_Record_JournalSection {#12381 #_mapperClass: "NPG_Content_Model_Mapper_JournalSection" #_formClass: "NPG_Content_Form_JournalSection" #_journal: NPG_Content_Model_Record_Journal {#12395 #_mapperClass: "NPG_Content_Model_Mapper_Journal" #_formClass: "NPG_Content_Form_Journal" #_name: null #_shortname: null #_frequence: null #_openAccess: null #_launchDate: null #_type: null #_category: null #_paywall: null #_adddate: null #_moddate: null #_lastEditedBy: null #_dirty: false #_lazyLoaded: true #_form: NPG_Content_Form_Journal {#12396 #_attribs: [] #_decorators: array:3 [ "FormElements" => array:2 [ …2] "HtmlTag" => array:2 [ …2] "Form" => array:2 [ …2] ] #_defaultDisplayGroupClass: "Zend_Form_DisplayGroup" #_description: null #_disableLoadDefaultDecorators: false #_displayGroupPrefixPaths: [] #_displayGroups: [] #_elementDecorators: array:1 [ 0 => "Composite" ] #_elementPrefixPaths: array:2 [ 0 => array:3 [ …3] 1 => array:3 [ …3] ] #_elements: array:11 [ "adddate" => Zend_Form_Element_Hidden {#12399 …30} "moddate" => Zend_Form_Element_Hidden {#12403 …30} "last_edited_by" => Zend_Form_Element_Hidden {#12407 …30} "name" => Zend_Form_Element_Text {#12411 …30} "shortname" => Zend_Form_Element_Text {#12415 …30} "frequence" => NPG_Form_Element_JournalFrequence {#12419 …35} "open_access" => Zend_Form_Element_Checkbox {#12423 …34} "paywall" => Zend_Form_Element_Checkbox {#12427 …34} "launch_date" => Zend_Form_Element_Text {#12431 …30} "type" => NPG_Form_Element_JournalType {#12435 …35} "category" => NPG_Form_Element_JournalCategory {#12439 …35} ] #_elementsBelongTo: null #_errorMessages: [] #_errorsExist: false #_errorsForced: false #_formOrder: null #_isArray: false #_legend: null #_loaders: array:2 [ "ELEMENT" => Zend_Loader_PluginLoader {#12397 …4} "DECORATOR" => Zend_Loader_PluginLoader {#12398 …4} ] #_methods: array:4 [ 0 => "delete" 1 => "get" 2 => "post" 3 => "put" ] #_order: array:11 [ "adddate" => null "moddate" => null "last_edited_by" => null "name" => null "shortname" => null "frequence" => null "open_access" => null "paywall" => null "launch_date" => null "type" => null "category" => null ] #_orderUpdated: true #_subFormPrefixPaths: [] #_subForms: [] #_translator: null #_translatorDisabled: false #_view: null #_isRendered: false } #_mapper: null #_id: 14 #_persisted: true #_validate: true #_foreignKeys: [] } #_name: "Editorial" #_pluralName: "Editorials" #_shortname: "ed" #_identifier: "ed" #_tocOrder: 2 #_presentInToc: true #_exportable: false #_adddate: Zend_Date {#12490 -_locale: "en_US" -_fractional: 0 -_precision: 3 -_unixTimestamp: "1343791229" -_timezone: "Asia/Tokyo" -_offset: -32400 -_syncronised: 0 #_dst: true } #_moddate: Zend_Date {#12491 -_locale: "en_US" -_fractional: 0 -_precision: 3 -_unixTimestamp: "1358702216" -_timezone: "Asia/Tokyo" -_offset: -32400 -_syncronised: 0 #_dst: true } #_lastEditedBy: NPG_System_Model_Record_User {#12393 #_mapperClass: "NPG_System_Model_Mapper_User" #_formClass: "NPG_System_Form_User" #_email: null #_firstname: null #_lastname: null #_password: null #_lastLogin: null #_lastFailedLogin: null #_nFailedLogin: 0 #_banned: null #_deleted: null #_adddate: null #_moddate: null #_dirty: false #_lazyLoaded: true #_form: NPG_System_Form_User {#12394 #_attribs: [] #_decorators: array:3 [ "FormElements" => array:2 [ …2] "HtmlTag" => array:2 [ …2] "Form" => array:2 [ …2] ] #_defaultDisplayGroupClass: "Zend_Form_DisplayGroup" #_description: null #_disableLoadDefaultDecorators: false #_displayGroupPrefixPaths: [] #_displayGroups: [] #_elementDecorators: array:1 [ 0 => "Composite" ] #_elementPrefixPaths: array:2 [ 0 => array:3 [ …3] 1 => array:3 [ …3] ] #_elements: array:11 [ "email" => Zend_Form_Element_Text {#12544 …30} "firstname" => Zend_Form_Element_Text {#12548 …30} "lastname" => Zend_Form_Element_Text {#12552 …30} "password" => Zend_Form_Element_Password {#12556 …31} "last_login" => Zend_Form_Element_Text {#12561 …30} "last_failed_login" => Zend_Form_Element_Text {#12566 …30} "n_failed_login" => Zend_Form_Element_Hidden {#12570 …30} "banned" => Zend_Form_Element_Checkbox {#12574 …34} "deleted" => Zend_Form_Element_Checkbox {#12578 …34} "adddate" => Zend_Form_Element_Text {#12582 …30} "moddate" => Zend_Form_Element_Text {#12586 …30} ] #_elementsBelongTo: null #_errorMessages: [] #_errorsExist: false #_errorsForced: false #_formOrder: null #_isArray: false #_legend: null #_loaders: array:2 [ "ELEMENT" => Zend_Loader_PluginLoader {#12542 …4} "DECORATOR" => Zend_Loader_PluginLoader {#12543 …4} ] #_methods: array:4 [ 0 => "delete" 1 => "get" 2 => "post" 3 => "put" ] #_order: array:11 [ "email" => null "firstname" => null "lastname" => null "password" => null "last_login" => null "last_failed_login" => null "n_failed_login" => null "banned" => null "deleted" => null "adddate" => null "moddate" => null ] #_orderUpdated: true #_subFormPrefixPaths: [] #_subForms: [] #_translator: null #_translatorDisabled: false #_view: null #_isRendered: false } #_mapper: null #_id: 1 #_persisted: true #_validate: true #_foreignKeys: [] } #_dirty: true #_lazyLoaded: false #_form: NPG_Content_Form_JournalSection {#12443 #_attribs: [] #_decorators: array:3 [ "FormElements" => array:2 [ "decorator" => "FormElements" "options" => null ] "HtmlTag" => array:2 [ "decorator" => "HtmlTag" "options" => array:2 [ …2] ] "Form" => array:2 [ "decorator" => "Form" "options" => null ] ] #_defaultDisplayGroupClass: "Zend_Form_DisplayGroup" #_description: null #_disableLoadDefaultDecorators: false #_displayGroupPrefixPaths: [] #_displayGroups: [] #_elementDecorators: array:1 [ 0 => "Composite" ] #_elementPrefixPaths: array:2 [ 0 => array:3 [ "prefix" => "NPG_Validate" "path" => "NPG/Validate/" "type" => "validate" ] 1 => array:3 [ "prefix" => "NPG_Filter" "path" => "NPG/Filter/" "type" => "filter" ] ] #_elements: array:11 [ "adddate" => Zend_Form_Element_Hidden {#12446 +helper: "formHidden" #_allowEmpty: true #_autoInsertNotEmptyValidator: true #_belongsTo: null #_decorators: array:1 [ …1] #_description: null #_disableLoadDefaultDecorators: false #_errorMessages: [] #_errors: [] #_errorMessageSeparator: "; " #_filters: [] #_ignore: false #_isArray: false #_isError: false #_isErrorForced: false #_label: null #_loaders: array:3 [ …3] #_messages: [] #_name: "adddate" #_order: null #_required: true #_translator: null #_translatorDisabled: false #_type: null #_validators: array:1 [ …1] #_validatorRules: [] #_value: null #_view: null #_isPartialRendering: false #_concatJustValuesInErrorMessage: false } "moddate" => Zend_Form_Element_Hidden {#12450 +helper: "formHidden" #_allowEmpty: true #_autoInsertNotEmptyValidator: true #_belongsTo: null #_decorators: array:1 [ …1] #_description: null #_disableLoadDefaultDecorators: false #_errorMessages: [] #_errors: [] #_errorMessageSeparator: "; " #_filters: [] #_ignore: false #_isArray: false #_isError: false #_isErrorForced: false #_label: null #_loaders: array:3 [ …3] #_messages: [] #_name: "moddate" #_order: null #_required: false #_translator: null #_translatorDisabled: false #_type: null #_validators: array:1 [ …1] #_validatorRules: [] #_value: null #_view: null #_isPartialRendering: false #_concatJustValuesInErrorMessage: false } "last_edited_by" => Zend_Form_Element_Hidden {#12454 +helper: "formHidden" #_allowEmpty: true #_autoInsertNotEmptyValidator: true #_belongsTo: null #_decorators: array:1 [ …1] #_description: null #_disableLoadDefaultDecorators: false #_errorMessages: [] #_errors: [] #_errorMessageSeparator: "; " #_filters: array:1 [ …1] #_ignore: false #_isArray: false #_isError: false #_isErrorForced: false #_label: null #_loaders: array:3 [ …3] #_messages: [] #_name: "last_edited_by" #_order: null #_required: true #_translator: null #_translatorDisabled: false #_type: null #_validators: array:2 [ …2] #_validatorRules: [] #_value: null #_view: null #_isPartialRendering: false #_concatJustValuesInErrorMessage: false } "journal_id" => Zend_Form_Element_Hidden {#12458 +helper: "formHidden" #_allowEmpty: true #_autoInsertNotEmptyValidator: true #_belongsTo: null #_decorators: array:1 [ …1] #_description: null #_disableLoadDefaultDecorators: false #_errorMessages: [] #_errors: [] #_errorMessageSeparator: "; " #_filters: array:1 [ …1] #_ignore: false #_isArray: false #_isError: false #_isErrorForced: false #_label: null #_loaders: array:3 [ …3] #_messages: [] #_name: "journal_id" #_order: null #_required: true #_translator: null #_translatorDisabled: false #_type: null #_validators: array:1 [ …1] #_validatorRules: [] #_value: null #_view: null #_isPartialRendering: false #_concatJustValuesInErrorMessage: false } "name" => Zend_Form_Element_Text {#12462 +helper: "formText" #_allowEmpty: true #_autoInsertNotEmptyValidator: true #_belongsTo: null #_decorators: array:2 [ …2] #_description: null #_disableLoadDefaultDecorators: false #_errorMessages: [] #_errors: [] #_errorMessageSeparator: "; " #_filters: [] #_ignore: false #_isArray: false #_isError: false #_isErrorForced: false #_label: "Name" #_loaders: array:3 [ …3] #_messages: [] #_name: "name" #_order: null #_required: true #_translator: null #_translatorDisabled: false #_type: null #_validators: array:2 [ …2] #_validatorRules: [] #_value: null #_view: null #_isPartialRendering: false #_concatJustValuesInErrorMessage: false } "plural_name" => Zend_Form_Element_Text {#12466 +helper: "formText" #_allowEmpty: true #_autoInsertNotEmptyValidator: true #_belongsTo: null #_decorators: array:1 [ …1] #_description: null #_disableLoadDefaultDecorators: false #_errorMessages: [] #_errors: [] #_errorMessageSeparator: "; " #_filters: [] #_ignore: false #_isArray: false #_isError: false #_isErrorForced: false #_label: "Plural name" #_loaders: array:3 [ …3] #_messages: [] #_name: "plural_name" #_order: null #_required: false #_translator: null #_translatorDisabled: false #_type: null #_validators: array:2 [ …2] #_validatorRules: [] #_value: null #_view: null #_isPartialRendering: false #_concatJustValuesInErrorMessage: false } "shortname" => Zend_Form_Element_Text {#12470 +helper: "formText" #_allowEmpty: true #_autoInsertNotEmptyValidator: true #_belongsTo: null #_decorators: array:1 [ …1] #_description: null #_disableLoadDefaultDecorators: false #_errorMessages: [] #_errors: [] #_errorMessageSeparator: "; " #_filters: [] #_ignore: false #_isArray: false #_isError: false #_isErrorForced: false #_label: "Shortname" #_loaders: array:3 [ …3] #_messages: [] #_name: "shortname" #_order: null #_required: false #_translator: null #_translatorDisabled: false #_type: null #_validators: array:1 [ …1] #_validatorRules: [] #_value: null #_view: null #_isPartialRendering: false #_concatJustValuesInErrorMessage: false } "identifier" => Zend_Form_Element_Text {#12474 +helper: "formText" #_allowEmpty: true #_autoInsertNotEmptyValidator: true #_belongsTo: null #_decorators: array:1 [ …1] #_description: null #_disableLoadDefaultDecorators: false #_errorMessages: [] #_errors: [] #_errorMessageSeparator: "; " #_filters: array:1 [ …1] #_ignore: false #_isArray: false #_isError: false #_isErrorForced: false #_label: "Identifier" #_loaders: array:3 [ …3] #_messages: [] #_name: "identifier" #_order: null #_required: false #_translator: null #_translatorDisabled: false #_type: null #_validators: array:1 [ …1] #_validatorRules: [] #_value: null #_view: null #_isPartialRendering: false #_concatJustValuesInErrorMessage: false } "toc_order" => Zend_Form_Element_Text {#12478 +helper: "formText" #_allowEmpty: true #_autoInsertNotEmptyValidator: true #_belongsTo: null #_decorators: array:1 [ …1] #_description: null #_disableLoadDefaultDecorators: false #_errorMessages: [] #_errors: [] #_errorMessageSeparator: "; " #_filters: array:1 [ …1] #_ignore: false #_isArray: false #_isError: false #_isErrorForced: false #_label: "TOC order" #_loaders: array:3 [ …3] #_messages: [] #_name: "toc_order" #_order: null #_required: true #_translator: null #_translatorDisabled: false #_type: null #_validators: array:1 [ …1] #_validatorRules: [] #_value: null #_view: null #_isPartialRendering: false #_concatJustValuesInErrorMessage: false } "present_in_toc" => Zend_Form_Element_Checkbox {#12482 +checked: false +helper: "formCheckbox" +options: array:2 [ …2] #_checkedValue: "1" #_uncheckedValue: "0" #_value: "0" #_allowEmpty: true #_autoInsertNotEmptyValidator: true #_belongsTo: null #_decorators: array:1 [ …1] #_description: null #_disableLoadDefaultDecorators: false #_errorMessages: [] #_errors: [] #_errorMessageSeparator: "; " #_filters: [] #_ignore: false #_isArray: false #_isError: false #_isErrorForced: false #_label: "Present in TOC" #_loaders: array:3 [ …3] #_messages: [] #_name: "present_in_toc" #_order: null #_required: true #_translator: null #_translatorDisabled: false #_type: null #_validators: array:1 [ …1] #_validatorRules: [] #_view: null #_isPartialRendering: false #_concatJustValuesInErrorMessage: false } "exportable" => Zend_Form_Element_Checkbox {#12486 +checked: false +helper: "formCheckbox" +options: array:2 [ …2] #_checkedValue: "1" #_uncheckedValue: "0" #_value: "0" #_allowEmpty: true #_autoInsertNotEmptyValidator: true #_belongsTo: null #_decorators: array:2 [ …2] #_description: null #_disableLoadDefaultDecorators: false #_errorMessages: [] #_errors: [] #_errorMessageSeparator: "; " #_filters: [] #_ignore: false #_isArray: false #_isError: false #_isErrorForced: false #_label: "Exportable" #_loaders: array:3 [ …3] #_messages: [] #_name: "exportable" #_order: null #_required: true #_translator: null #_translatorDisabled: false #_type: null #_validators: array:1 [ …1] #_validatorRules: [] #_view: null #_isPartialRendering: false #_concatJustValuesInErrorMessage: false } ] #_elementsBelongTo: null #_errorMessages: [] #_errorsExist: false #_errorsForced: false #_formOrder: null #_isArray: false #_legend: null #_loaders: array:2 [ "ELEMENT" => Zend_Loader_PluginLoader {#12444 #_loadedPluginPaths: [] #_loadedPlugins: array:3 [ …3] #_prefixToPaths: array:2 [ …2] #_useStaticRegistry: null } "DECORATOR" => Zend_Loader_PluginLoader {#12445 #_loadedPluginPaths: [] #_loadedPlugins: [] #_prefixToPaths: array:2 [ …2] #_useStaticRegistry: null } ] #_methods: array:4 [ 0 => "delete" 1 => "get" 2 => "post" 3 => "put" ] #_order: array:11 [ "adddate" => null "moddate" => null "last_edited_by" => null "journal_id" => null "name" => null "plural_name" => null "shortname" => null "identifier" => null "toc_order" => null "present_in_toc" => null "exportable" => null ] #_orderUpdated: true #_subFormPrefixPaths: [] #_subForms: [] #_translator: null #_translatorDisabled: false #_view: null #_isRendered: false } #_mapper: null #_id: 14 #_persisted: true #_validate: false #_foreignKeys: array:2 [ "journal_id" => "14" "last_edited_by" => "1" ] } 24 => NPG_Content_Model_Record_JournalSection {#12492 #_mapperClass: "NPG_Content_Model_Mapper_JournalSection" #_formClass: "NPG_Content_Form_JournalSection" #_journal: NPG_Content_Model_Record_Journal {#12494 #_mapperClass: "NPG_Content_Model_Mapper_Journal" #_formClass: "NPG_Content_Form_Journal" #_name: null #_shortname: null #_frequence: null #_openAccess: null #_launchDate: null #_type: null #_category: null #_paywall: null #_adddate: null #_moddate: null #_lastEditedBy: null #_dirty: false #_lazyLoaded: true #_form: NPG_Content_Form_Journal {#12538 #_attribs: [] #_decorators: array:3 [ "FormElements" => array:2 [ …2] "HtmlTag" => array:2 [ …2] "Form" => array:2 [ …2] ] #_defaultDisplayGroupClass: "Zend_Form_DisplayGroup" #_description: null #_disableLoadDefaultDecorators: false #_displayGroupPrefixPaths: [] #_displayGroups: [] #_elementDecorators: array:1 [ 0 => "Composite" ] #_elementPrefixPaths: array:2 [ 0 => array:3 [ …3] 1 => array:3 [ …3] ] #_elements: array:11 [ "adddate" => Zend_Form_Element_Hidden {#12539 …30} "moddate" => Zend_Form_Element_Hidden {#12535 …30} "last_edited_by" => Zend_Form_Element_Hidden {#12531 …30} "name" => Zend_Form_Element_Text {#12527 …30} "shortname" => Zend_Form_Element_Text {#12523 …30} "frequence" => NPG_Form_Element_JournalFrequence {#12520 …35} "open_access" => Zend_Form_Element_Checkbox {#12516 …34} "paywall" => Zend_Form_Element_Checkbox {#12511 …34} "launch_date" => Zend_Form_Element_Text {#12507 …30} "type" => NPG_Form_Element_JournalType {#12503 …35} "category" => NPG_Form_Element_JournalCategory {#12499 …35} ] #_elementsBelongTo: null #_errorMessages: [] #_errorsExist: false #_errorsForced: false #_formOrder: null #_isArray: false #_legend: null #_loaders: array:2 [ "ELEMENT" => Zend_Loader_PluginLoader {#12541 …4} "DECORATOR" => Zend_Loader_PluginLoader {#12540 …4} ] #_methods: array:4 [ 0 => "delete" 1 => "get" 2 => "post" 3 => "put" ] #_order: array:11 [ "adddate" => null "moddate" => null "last_edited_by" => null "name" => null "shortname" => null "frequence" => null "open_access" => null "paywall" => null "launch_date" => null "type" => null "category" => null ] #_orderUpdated: true #_subFormPrefixPaths: [] #_subForms: [] #_translator: null #_translatorDisabled: false #_view: null #_isRendered: false } #_mapper: null #_id: 14 #_persisted: true #_validate: true #_foreignKeys: [] } #_name: "News" #_pluralName: "News" #_shortname: "nw" #_identifier: "nw" #_tocOrder: 10 #_presentInToc: true #_exportable: true #_adddate: Zend_Date {#12638 -_locale: "en_US" -_fractional: 0 -_precision: 3 -_unixTimestamp: "1343791229" -_timezone: "Asia/Tokyo" -_offset: -32400 -_syncronised: 0 #_dst: true } #_moddate: Zend_Date {#12639 -_locale: "en_US" -_fractional: 0 -_precision: 3 -_unixTimestamp: "1381783004" -_timezone: "Asia/Tokyo" -_offset: -32400 -_syncronised: 0 #_dst: true } #_lastEditedBy: NPG_System_Model_Record_User {#12493 #_mapperClass: "NPG_System_Model_Mapper_User" #_formClass: "NPG_System_Form_User" #_email: null #_firstname: null #_lastname: null #_password: null #_lastLogin: null #_lastFailedLogin: null #_nFailedLogin: 0 #_banned: null #_deleted: null #_adddate: null #_moddate: null #_dirty: false #_lazyLoaded: true #_form: NPG_System_Form_User {#12495 #_attribs: [] #_decorators: array:3 [ "FormElements" => array:2 [ …2] "HtmlTag" => array:2 [ …2] "Form" => array:2 [ …2] ] #_defaultDisplayGroupClass: "Zend_Form_DisplayGroup" #_description: null #_disableLoadDefaultDecorators: false #_displayGroupPrefixPaths: [] #_displayGroups: [] #_elementDecorators: array:1 [ 0 => "Composite" ] #_elementPrefixPaths: array:2 [ 0 => array:3 [ …3] 1 => array:3 [ …3] ] #_elements: array:11 [ "email" => Zend_Form_Element_Text {#12692 …30} "firstname" => Zend_Form_Element_Text {#12696 …30} "lastname" => Zend_Form_Element_Text {#12700 …30} "password" => Zend_Form_Element_Password {#12704 …31} "last_login" => Zend_Form_Element_Text {#12709 …30} "last_failed_login" => Zend_Form_Element_Text {#12714 …30} "n_failed_login" => Zend_Form_Element_Hidden {#12718 …30} "banned" => Zend_Form_Element_Checkbox {#12722 …34} "deleted" => Zend_Form_Element_Checkbox {#12726 …34} "adddate" => Zend_Form_Element_Text {#12730 …30} "moddate" => Zend_Form_Element_Text {#12734 …30} ] #_elementsBelongTo: null #_errorMessages: [] #_errorsExist: false #_errorsForced: false #_formOrder: null #_isArray: false #_legend: null #_loaders: array:2 [ "ELEMENT" => Zend_Loader_PluginLoader {#12690 …4} "DECORATOR" => Zend_Loader_PluginLoader {#12691 …4} ] #_methods: array:4 [ 0 => "delete" 1 => "get" 2 => "post" 3 => "put" ] #_order: array:11 [ "email" => null "firstname" => null "lastname" => null "password" => null "last_login" => null "last_failed_login" => null "n_failed_login" => null "banned" => null "deleted" => null "adddate" => null "moddate" => null ] #_orderUpdated: true #_subFormPrefixPaths: [] #_subForms: [] #_translator: null #_translatorDisabled: false #_view: null #_isRendered: false } #_mapper: null #_id: 1 #_persisted: true #_validate: true #_foreignKeys: [] } #_dirty: true #_lazyLoaded: false #_form: NPG_Content_Form_JournalSection {#12591 #_attribs: [] #_decorators: array:3 [ "FormElements" => array:2 [ "decorator" => "FormElements" "options" => null ] "HtmlTag" => array:2 [ "decorator" => "HtmlTag" "options" => array:2 [ …2] ] "Form" => array:2 [ "decorator" => "Form" "options" => null ] ] #_defaultDisplayGroupClass: "Zend_Form_DisplayGroup" #_description: null #_disableLoadDefaultDecorators: false #_displayGroupPrefixPaths: [] #_displayGroups: [] #_elementDecorators: array:1 [ 0 => "Composite" ] #_elementPrefixPaths: array:2 [ 0 => array:3 [ "prefix" => "NPG_Validate" "path" => "NPG/Validate/" "type" => "validate" ] 1 => array:3 [ "prefix" => "NPG_Filter" "path" => "NPG/Filter/" "type" => "filter" ] ] #_elements: array:11 [ "adddate" => Zend_Form_Element_Hidden {#12594 +helper: "formHidden" #_allowEmpty: true #_autoInsertNotEmptyValidator: true #_belongsTo: null #_decorators: array:1 [ …1] #_description: null #_disableLoadDefaultDecorators: false #_errorMessages: [] #_errors: [] #_errorMessageSeparator: "; " #_filters: [] #_ignore: false #_isArray: false #_isError: false #_isErrorForced: false #_label: null #_loaders: array:3 [ …3] #_messages: [] #_name: "adddate" #_order: null #_required: true #_translator: null #_translatorDisabled: false #_type: null #_validators: array:1 [ …1] #_validatorRules: [] #_value: null #_view: null #_isPartialRendering: false #_concatJustValuesInErrorMessage: false } "moddate" => Zend_Form_Element_Hidden {#12598 +helper: "formHidden" #_allowEmpty: true #_autoInsertNotEmptyValidator: true #_belongsTo: null #_decorators: array:1 [ …1] #_description: null #_disableLoadDefaultDecorators: false #_errorMessages: [] #_errors: [] #_errorMessageSeparator: "; " #_filters: [] #_ignore: false #_isArray: false #_isError: false #_isErrorForced: false #_label: null #_loaders: array:3 [ …3] #_messages: [] #_name: "moddate" #_order: null #_required: false #_translator: null #_translatorDisabled: false #_type: null #_validators: array:1 [ …1] #_validatorRules: [] #_value: null #_view: null #_isPartialRendering: false #_concatJustValuesInErrorMessage: false } "last_edited_by" => Zend_Form_Element_Hidden {#12602 +helper: "formHidden" #_allowEmpty: true #_autoInsertNotEmptyValidator: true #_belongsTo: null #_decorators: array:1 [ …1] #_description: null #_disableLoadDefaultDecorators: false #_errorMessages: [] #_errors: [] #_errorMessageSeparator: "; " #_filters: array:1 [ …1] #_ignore: false #_isArray: false #_isError: false #_isErrorForced: false #_label: null #_loaders: array:3 [ …3] #_messages: [] #_name: "last_edited_by" #_order: null #_required: true #_translator: null #_translatorDisabled: false #_type: null #_validators: array:2 [ …2] #_validatorRules: [] #_value: null #_view: null #_isPartialRendering: false #_concatJustValuesInErrorMessage: false } "journal_id" => Zend_Form_Element_Hidden {#12606 +helper: "formHidden" #_allowEmpty: true #_autoInsertNotEmptyValidator: true #_belongsTo: null #_decorators: array:1 [ …1] #_description: null #_disableLoadDefaultDecorators: false #_errorMessages: [] #_errors: [] #_errorMessageSeparator: "; " #_filters: array:1 [ …1] #_ignore: false #_isArray: false #_isError: false #_isErrorForced: false #_label: null #_loaders: array:3 [ …3] #_messages: [] #_name: "journal_id" #_order: null #_required: true #_translator: null #_translatorDisabled: false #_type: null #_validators: array:1 [ …1] #_validatorRules: [] #_value: null #_view: null #_isPartialRendering: false #_concatJustValuesInErrorMessage: false } "name" => Zend_Form_Element_Text {#12610 +helper: "formText" #_allowEmpty: true #_autoInsertNotEmptyValidator: true #_belongsTo: null #_decorators: array:2 [ …2] #_description: null #_disableLoadDefaultDecorators: false #_errorMessages: [] #_errors: [] #_errorMessageSeparator: "; " #_filters: [] #_ignore: false #_isArray: false #_isError: false #_isErrorForced: false #_label: "Name" #_loaders: array:3 [ …3] #_messages: [] #_name: "name" #_order: null #_required: true #_translator: null #_translatorDisabled: false #_type: null #_validators: array:2 [ …2] #_validatorRules: [] #_value: null #_view: null #_isPartialRendering: false #_concatJustValuesInErrorMessage: false } "plural_name" => Zend_Form_Element_Text {#12614 +helper: "formText" #_allowEmpty: true #_autoInsertNotEmptyValidator: true #_belongsTo: null #_decorators: array:1 [ …1] #_description: null #_disableLoadDefaultDecorators: false #_errorMessages: [] #_errors: [] #_errorMessageSeparator: "; " #_filters: [] #_ignore: false #_isArray: false #_isError: false #_isErrorForced: false #_label: "Plural name" #_loaders: array:3 [ …3] #_messages: [] #_name: "plural_name" #_order: null #_required: false #_translator: null #_translatorDisabled: false #_type: null #_validators: array:2 [ …2] #_validatorRules: [] #_value: null #_view: null #_isPartialRendering: false #_concatJustValuesInErrorMessage: false } "shortname" => Zend_Form_Element_Text {#12618 +helper: "formText" #_allowEmpty: true #_autoInsertNotEmptyValidator: true #_belongsTo: null #_decorators: array:1 [ …1] #_description: null #_disableLoadDefaultDecorators: false #_errorMessages: [] #_errors: [] #_errorMessageSeparator: "; " #_filters: [] #_ignore: false #_isArray: false #_isError: false #_isErrorForced: false #_label: "Shortname" #_loaders: array:3 [ …3] #_messages: [] #_name: "shortname" #_order: null #_required: false #_translator: null #_translatorDisabled: false #_type: null #_validators: array:1 [ …1] #_validatorRules: [] #_value: null #_view: null #_isPartialRendering: false #_concatJustValuesInErrorMessage: false } "identifier" => Zend_Form_Element_Text {#12622 +helper: "formText" #_allowEmpty: true #_autoInsertNotEmptyValidator: true #_belongsTo: null #_decorators: array:1 [ …1] #_description: null #_disableLoadDefaultDecorators: false #_errorMessages: [] #_errors: [] #_errorMessageSeparator: "; " #_filters: array:1 [ …1] #_ignore: false #_isArray: false #_isError: false #_isErrorForced: false #_label: "Identifier" #_loaders: array:3 [ …3] #_messages: [] #_name: "identifier" #_order: null #_required: false #_translator: null #_translatorDisabled: false #_type: null #_validators: array:1 [ …1] #_validatorRules: [] #_value: null #_view: null #_isPartialRendering: false #_concatJustValuesInErrorMessage: false } "toc_order" => Zend_Form_Element_Text {#12626 +helper: "formText" #_allowEmpty: true #_autoInsertNotEmptyValidator: true #_belongsTo: null #_decorators: array:1 [ …1] #_description: null #_disableLoadDefaultDecorators: false #_errorMessages: [] #_errors: [] #_errorMessageSeparator: "; " #_filters: array:1 [ …1] #_ignore: false #_isArray: false #_isError: false #_isErrorForced: false #_label: "TOC order" #_loaders: array:3 [ …3] #_messages: [] #_name: "toc_order" #_order: null #_required: true #_translator: null #_translatorDisabled: false #_type: null #_validators: array:1 [ …1] #_validatorRules: [] #_value: null #_view: null #_isPartialRendering: false #_concatJustValuesInErrorMessage: false } "present_in_toc" => Zend_Form_Element_Checkbox {#12630 +checked: false +helper: "formCheckbox" +options: array:2 [ …2] #_checkedValue: "1" #_uncheckedValue: "0" #_value: "0" #_allowEmpty: true #_autoInsertNotEmptyValidator: true #_belongsTo: null #_decorators: array:1 [ …1] #_description: null #_disableLoadDefaultDecorators: false #_errorMessages: [] #_errors: [] #_errorMessageSeparator: "; " #_filters: [] #_ignore: false #_isArray: false #_isError: false #_isErrorForced: false #_label: "Present in TOC" #_loaders: array:3 [ …3] #_messages: [] #_name: "present_in_toc" #_order: null #_required: true #_translator: null #_translatorDisabled: false #_type: null #_validators: array:1 [ …1] #_validatorRules: [] #_view: null #_isPartialRendering: false #_concatJustValuesInErrorMessage: false } "exportable" => Zend_Form_Element_Checkbox {#12634 +checked: false +helper: "formCheckbox" +options: array:2 [ …2] #_checkedValue: "1" #_uncheckedValue: "0" #_value: "0" #_allowEmpty: true #_autoInsertNotEmptyValidator: true #_belongsTo: null #_decorators: array:2 [ …2] #_description: null #_disableLoadDefaultDecorators: false #_errorMessages: [] #_errors: [] #_errorMessageSeparator: "; " #_filters: [] #_ignore: false #_isArray: false #_isError: false #_isErrorForced: false #_label: "Exportable" #_loaders: array:3 [ …3] #_messages: [] #_name: "exportable" #_order: null #_required: true #_translator: null #_translatorDisabled: false #_type: null #_validators: array:1 [ …1] #_validatorRules: [] #_view: null #_isPartialRendering: false #_concatJustValuesInErrorMessage: false } ] #_elementsBelongTo: null #_errorMessages: [] #_errorsExist: false #_errorsForced: false #_formOrder: null #_isArray: false #_legend: null #_loaders: array:2 [ "ELEMENT" => Zend_Loader_PluginLoader {#12592 #_loadedPluginPaths: [] #_loadedPlugins: array:3 [ …3] #_prefixToPaths: array:2 [ …2] #_useStaticRegistry: null } "DECORATOR" => Zend_Loader_PluginLoader {#12593 #_loadedPluginPaths: [] #_loadedPlugins: [] #_prefixToPaths: array:2 [ …2] #_useStaticRegistry: null } ] #_methods: array:4 [ 0 => "delete" 1 => "get" 2 => "post" 3 => "put" ] #_order: array:11 [ "adddate" => null "moddate" => null "last_edited_by" => null "journal_id" => null "name" => null "plural_name" => null "shortname" => null "identifier" => null "toc_order" => null "present_in_toc" => null "exportable" => null ] #_orderUpdated: true #_subFormPrefixPaths: [] #_subForms: [] #_translator: null #_translatorDisabled: false #_view: null #_isRendered: false } #_mapper: null #_id: 24 #_persisted: true #_validate: false #_foreignKeys: array:2 [ "journal_id" => "14" "last_edited_by" => "1" ] } 30 => NPG_Content_Model_Record_JournalSection {#12640 #_mapperClass: "NPG_Content_Model_Mapper_JournalSection" #_formClass: "NPG_Content_Form_JournalSection" #_journal: NPG_Content_Model_Record_Journal {#12642 #_mapperClass: "NPG_Content_Model_Mapper_Journal" #_formClass: "NPG_Content_Form_Journal" #_name: null #_shortname: null #_frequence: null #_openAccess: null #_launchDate: null #_type: null #_category: null #_paywall: null #_adddate: null #_moddate: null #_lastEditedBy: null #_dirty: false #_lazyLoaded: true #_form: NPG_Content_Form_Journal {#12686 #_attribs: [] #_decorators: array:3 [ "FormElements" => array:2 [ …2] "HtmlTag" => array:2 [ …2] "Form" => array:2 [ …2] ] #_defaultDisplayGroupClass: "Zend_Form_DisplayGroup" #_description: null #_disableLoadDefaultDecorators: false #_displayGroupPrefixPaths: [] #_displayGroups: [] #_elementDecorators: array:1 [ 0 => "Composite" ] #_elementPrefixPaths: array:2 [ 0 => array:3 [ …3] 1 => array:3 [ …3] ] #_elements: array:11 [ "adddate" => Zend_Form_Element_Hidden {#12687 …30} "moddate" => Zend_Form_Element_Hidden {#12683 …30} "last_edited_by" => Zend_Form_Element_Hidden {#12679 …30} "name" => Zend_Form_Element_Text {#12675 …30} "shortname" => Zend_Form_Element_Text {#12671 …30} "frequence" => NPG_Form_Element_JournalFrequence {#12668 …35} "open_access" => Zend_Form_Element_Checkbox {#12664 …34} "paywall" => Zend_Form_Element_Checkbox {#12659 …34} "launch_date" => Zend_Form_Element_Text {#12655 …30} "type" => NPG_Form_Element_JournalType {#12651 …35} "category" => NPG_Form_Element_JournalCategory {#12647 …35} ] #_elementsBelongTo: null #_errorMessages: [] #_errorsExist: false #_errorsForced: false #_formOrder: null #_isArray: false #_legend: null #_loaders: array:2 [ "ELEMENT" => Zend_Loader_PluginLoader {#12689 …4} "DECORATOR" => Zend_Loader_PluginLoader {#12688 …4} ] #_methods: array:4 [ 0 => "delete" 1 => "get" 2 => "post" 3 => "put" ] #_order: array:11 [ "adddate" => null "moddate" => null "last_edited_by" => null "name" => null "shortname" => null "frequence" => null "open_access" => null "paywall" => null "launch_date" => null "type" => null "category" => null ] #_orderUpdated: true #_subFormPrefixPaths: [] #_subForms: [] #_translator: null #_translatorDisabled: false #_view: null #_isRendered: false } #_mapper: null #_id: 14 #_persisted: true #_validate: true #_foreignKeys: [] } #_name: "News Features" #_pluralName: "News Features" #_shortname: "nf" #_identifier: "nf" #_tocOrder: 20 #_presentInToc: true #_exportable: true #_adddate: Zend_Date {#12786 -_locale: "en_US" -_fractional: 0 -_precision: 3 -_unixTimestamp: "1343791230" -_timezone: "Asia/Tokyo" -_offset: -32400 -_syncronised: 0 #_dst: true } #_moddate: Zend_Date {#12787 -_locale: "en_US" -_fractional: 0 -_precision: 3 -_unixTimestamp: "1344461350" -_timezone: "Asia/Tokyo" -_offset: -32400 -_syncronised: 0 #_dst: true } #_lastEditedBy: NPG_System_Model_Record_User {#12641 #_mapperClass: "NPG_System_Model_Mapper_User" #_formClass: "NPG_System_Form_User" #_email: null #_firstname: null #_lastname: null #_password: null #_lastLogin: null #_lastFailedLogin: null #_nFailedLogin: 0 #_banned: null #_deleted: null #_adddate: null #_moddate: null #_dirty: false #_lazyLoaded: true #_form: NPG_System_Form_User {#12643 #_attribs: [] #_decorators: array:3 [ "FormElements" => array:2 [ …2] "HtmlTag" => array:2 [ …2] "Form" => array:2 [ …2] ] #_defaultDisplayGroupClass: "Zend_Form_DisplayGroup" #_description: null #_disableLoadDefaultDecorators: false #_displayGroupPrefixPaths: [] #_displayGroups: [] #_elementDecorators: array:1 [ 0 => "Composite" ] #_elementPrefixPaths: array:2 [ 0 => array:3 [ …3] 1 => array:3 [ …3] ] #_elements: array:11 [ "email" => Zend_Form_Element_Text {#12840 …30} "firstname" => Zend_Form_Element_Text {#12844 …30} "lastname" => Zend_Form_Element_Text {#12848 …30} "password" => Zend_Form_Element_Password {#12852 …31} "last_login" => Zend_Form_Element_Text {#12857 …30} "last_failed_login" => Zend_Form_Element_Text {#12862 …30} "n_failed_login" => Zend_Form_Element_Hidden {#12866 …30} "banned" => Zend_Form_Element_Checkbox {#12870 …34} "deleted" => Zend_Form_Element_Checkbox {#12874 …34} "adddate" => Zend_Form_Element_Text {#12878 …30} "moddate" => Zend_Form_Element_Text {#12882 …30} ] #_elementsBelongTo: null #_errorMessages: [] #_errorsExist: false #_errorsForced: false #_formOrder: null #_isArray: false #_legend: null #_loaders: array:2 [ "ELEMENT" => Zend_Loader_PluginLoader {#12838 …4} "DECORATOR" => Zend_Loader_PluginLoader {#12839 …4} ] #_methods: array:4 [ 0 => "delete" 1 => "get" 2 => "post" 3 => "put" ] #_order: array:11 [ "email" => null "firstname" => null "lastname" => null "password" => null "last_login" => null "last_failed_login" => null "n_failed_login" => null "banned" => null "deleted" => null "adddate" => null "moddate" => null ] #_orderUpdated: true #_subFormPrefixPaths: [] #_subForms: [] #_translator: null #_translatorDisabled: false #_view: null #_isRendered: false } #_mapper: null #_id: 1 #_persisted: true #_validate: true #_foreignKeys: [] } #_dirty: true #_lazyLoaded: false #_form: NPG_Content_Form_JournalSection {#12739 #_attribs: [] #_decorators: array:3 [ "FormElements" => array:2 [ "decorator" => "FormElements" "options" => null ] "HtmlTag" => array:2 [ "decorator" => "HtmlTag" "options" => array:2 [ …2] ] "Form" => array:2 [ "decorator" => "Form" "options" => null ] ] #_defaultDisplayGroupClass: "Zend_Form_DisplayGroup" #_description: null #_disableLoadDefaultDecorators: false #_displayGroupPrefixPaths: [] #_displayGroups: [] #_elementDecorators: array:1 [ 0 => "Composite" ] #_elementPrefixPaths: array:2 [ 0 => array:3 [ "prefix" => "NPG_Validate" "path" => "NPG/Validate/" "type" => "validate" ] 1 => array:3 [ "prefix" => "NPG_Filter" "path" => "NPG/Filter/" "type" => "filter" ] ] #_elements: array:11 [ "adddate" => Zend_Form_Element_Hidden {#12742 +helper: "formHidden" #_allowEmpty: true #_autoInsertNotEmptyValidator: true #_belongsTo: null #_decorators: array:1 [ …1] #_description: null #_disableLoadDefaultDecorators: false #_errorMessages: [] #_errors: [] #_errorMessageSeparator: "; " #_filters: [] #_ignore: false #_isArray: false #_isError: false #_isErrorForced: false #_label: null #_loaders: array:3 [ …3] #_messages: [] #_name: "adddate" #_order: null #_required: true #_translator: null #_translatorDisabled: false #_type: null #_validators: array:1 [ …1] #_validatorRules: [] #_value: null #_view: null #_isPartialRendering: false #_concatJustValuesInErrorMessage: false } "moddate" => Zend_Form_Element_Hidden {#12746 +helper: "formHidden" #_allowEmpty: true #_autoInsertNotEmptyValidator: true #_belongsTo: null #_decorators: array:1 [ …1] #_description: null #_disableLoadDefaultDecorators: false #_errorMessages: [] #_errors: [] #_errorMessageSeparator: "; " #_filters: [] #_ignore: false #_isArray: false #_isError: false #_isErrorForced: false #_label: null #_loaders: array:3 [ …3] #_messages: [] #_name: "moddate" #_order: null #_required: false #_translator: null #_translatorDisabled: false #_type: null #_validators: array:1 [ …1] #_validatorRules: [] #_value: null #_view: null #_isPartialRendering: false #_concatJustValuesInErrorMessage: false } "last_edited_by" => Zend_Form_Element_Hidden {#12750 +helper: "formHidden" #_allowEmpty: true #_autoInsertNotEmptyValidator: true #_belongsTo: null #_decorators: array:1 [ …1] #_description: null #_disableLoadDefaultDecorators: false #_errorMessages: [] #_errors: [] #_errorMessageSeparator: "; " #_filters: array:1 [ …1] #_ignore: false #_isArray: false #_isError: false #_isErrorForced: false #_label: null #_loaders: array:3 [ …3] #_messages: [] #_name: "last_edited_by" #_order: null #_required: true #_translator: null #_translatorDisabled: false #_type: null #_validators: array:2 [ …2] #_validatorRules: [] #_value: null #_view: null #_isPartialRendering: false #_concatJustValuesInErrorMessage: false } "journal_id" => Zend_Form_Element_Hidden {#12754 +helper: "formHidden" #_allowEmpty: true #_autoInsertNotEmptyValidator: true #_belongsTo: null #_decorators: array:1 [ …1] #_description: null #_disableLoadDefaultDecorators: false #_errorMessages: [] #_errors: [] #_errorMessageSeparator: "; " #_filters: array:1 [ …1] #_ignore: false #_isArray: false #_isError: false #_isErrorForced: false #_label: null #_loaders: array:3 [ …3] #_messages: [] #_name: "journal_id" #_order: null #_required: true #_translator: null #_translatorDisabled: false #_type: null #_validators: array:1 [ …1] #_validatorRules: [] #_value: null #_view: null #_isPartialRendering: false #_concatJustValuesInErrorMessage: false } "name" => Zend_Form_Element_Text {#12758 +helper: "formText" #_allowEmpty: true #_autoInsertNotEmptyValidator: true #_belongsTo: null #_decorators: array:2 [ …2] #_description: null #_disableLoadDefaultDecorators: false #_errorMessages: [] #_errors: [] #_errorMessageSeparator: "; " #_filters: [] #_ignore: false #_isArray: false #_isError: false #_isErrorForced: false #_label: "Name" #_loaders: array:3 [ …3] #_messages: [] #_name: "name" #_order: null #_required: true #_translator: null #_translatorDisabled: false #_type: null #_validators: array:2 [ …2] #_validatorRules: [] #_value: null #_view: null #_isPartialRendering: false #_concatJustValuesInErrorMessage: false } "plural_name" => Zend_Form_Element_Text {#12762 +helper: "formText" #_allowEmpty: true #_autoInsertNotEmptyValidator: true #_belongsTo: null #_decorators: array:1 [ …1] #_description: null #_disableLoadDefaultDecorators: false #_errorMessages: [] #_errors: [] #_errorMessageSeparator: "; " #_filters: [] #_ignore: false #_isArray: false #_isError: false #_isErrorForced: false #_label: "Plural name" #_loaders: array:3 [ …3] #_messages: [] #_name: "plural_name" #_order: null #_required: false #_translator: null #_translatorDisabled: false #_type: null #_validators: array:2 [ …2] #_validatorRules: [] #_value: null #_view: null #_isPartialRendering: false #_concatJustValuesInErrorMessage: false } "shortname" => Zend_Form_Element_Text {#12766 +helper: "formText" #_allowEmpty: true #_autoInsertNotEmptyValidator: true #_belongsTo: null #_decorators: array:1 [ …1] #_description: null #_disableLoadDefaultDecorators: false #_errorMessages: [] #_errors: [] #_errorMessageSeparator: "; " #_filters: [] #_ignore: false #_isArray: false #_isError: false #_isErrorForced: false #_label: "Shortname" #_loaders: array:3 [ …3] #_messages: [] #_name: "shortname" #_order: null #_required: false #_translator: null #_translatorDisabled: false #_type: null #_validators: array:1 [ …1] #_validatorRules: [] #_value: null #_view: null #_isPartialRendering: false #_concatJustValuesInErrorMessage: false } "identifier" => Zend_Form_Element_Text {#12770 +helper: "formText" #_allowEmpty: true #_autoInsertNotEmptyValidator: true #_belongsTo: null #_decorators: array:1 [ …1] #_description: null #_disableLoadDefaultDecorators: false #_errorMessages: [] #_errors: [] #_errorMessageSeparator: "; " #_filters: array:1 [ …1] #_ignore: false #_isArray: false #_isError: false #_isErrorForced: false #_label: "Identifier" #_loaders: array:3 [ …3] #_messages: [] #_name: "identifier" #_order: null #_required: false #_translator: null #_translatorDisabled: false #_type: null #_validators: array:1 [ …1] #_validatorRules: [] #_value: null #_view: null #_isPartialRendering: false #_concatJustValuesInErrorMessage: false } "toc_order" => Zend_Form_Element_Text {#12774 +helper: "formText" #_allowEmpty: true #_autoInsertNotEmptyValidator: true #_belongsTo: null #_decorators: array:1 [ …1] #_description: null #_disableLoadDefaultDecorators: false #_errorMessages: [] #_errors: [] #_errorMessageSeparator: "; " #_filters: array:1 [ …1] #_ignore: false #_isArray: false #_isError: false #_isErrorForced: false #_label: "TOC order" #_loaders: array:3 [ …3] #_messages: [] #_name: "toc_order" #_order: null #_required: true #_translator: null #_translatorDisabled: false #_type: null #_validators: array:1 [ …1] #_validatorRules: [] #_value: null #_view: null #_isPartialRendering: false #_concatJustValuesInErrorMessage: false } "present_in_toc" => Zend_Form_Element_Checkbox {#12778 +checked: false +helper: "formCheckbox" +options: array:2 [ …2] #_checkedValue: "1" #_uncheckedValue: "0" #_value: "0" #_allowEmpty: true #_autoInsertNotEmptyValidator: true #_belongsTo: null #_decorators: array:1 [ …1] #_description: null #_disableLoadDefaultDecorators: false #_errorMessages: [] #_errors: [] #_errorMessageSeparator: "; " #_filters: [] #_ignore: false #_isArray: false #_isError: false #_isErrorForced: false #_label: "Present in TOC" #_loaders: array:3 [ …3] #_messages: [] #_name: "present_in_toc" #_order: null #_required: true #_translator: null #_translatorDisabled: false #_type: null #_validators: array:1 [ …1] #_validatorRules: [] #_view: null #_isPartialRendering: false #_concatJustValuesInErrorMessage: false } "exportable" => Zend_Form_Element_Checkbox {#12782 +checked: false +helper: "formCheckbox" +options: array:2 [ …2] #_checkedValue: "1" #_uncheckedValue: "0" #_value: "0" #_allowEmpty: true #_autoInsertNotEmptyValidator: true #_belongsTo: null #_decorators: array:2 [ …2] #_description: null #_disableLoadDefaultDecorators: false #_errorMessages: [] #_errors: [] #_errorMessageSeparator: "; " #_filters: [] #_ignore: false #_isArray: false #_isError: false #_isErrorForced: false #_label: "Exportable" #_loaders: array:3 [ …3] #_messages: [] #_name: "exportable" #_order: null #_required: true #_translator: null #_translatorDisabled: false #_type: null #_validators: array:1 [ …1] #_validatorRules: [] #_view: null #_isPartialRendering: false #_concatJustValuesInErrorMessage: false } ] #_elementsBelongTo: null #_errorMessages: [] #_errorsExist: false #_errorsForced: false #_formOrder: null #_isArray: false #_legend: null #_loaders: array:2 [ "ELEMENT" => Zend_Loader_PluginLoader {#12740 #_loadedPluginPaths: [] #_loadedPlugins: array:3 [ …3] #_prefixToPaths: array:2 [ …2] #_useStaticRegistry: null } "DECORATOR" => Zend_Loader_PluginLoader {#12741 #_loadedPluginPaths: [] #_loadedPlugins: [] #_prefixToPaths: array:2 [ …2] #_useStaticRegistry: null } ] #_methods: array:4 [ 0 => "delete" 1 => "get" 2 => "post" 3 => "put" ] #_order: array:11 [ "adddate" => null "moddate" => null "last_edited_by" => null "journal_id" => null "name" => null "plural_name" => null "shortname" => null "identifier" => null "toc_order" => null "present_in_toc" => null "exportable" => null ] #_orderUpdated: true #_subFormPrefixPaths: [] #_subForms: [] #_translator: null #_translatorDisabled: false #_view: null #_isRendered: false } #_mapper: null #_id: 30 #_persisted: true #_validate: false #_foreignKeys: array:2 [ "journal_id" => "14" "last_edited_by" => "1" ] } 27 => NPG_Content_Model_Record_JournalSection {#12788 #_mapperClass: "NPG_Content_Model_Mapper_JournalSection" #_formClass: "NPG_Content_Form_JournalSection" #_journal: NPG_Content_Model_Record_Journal {#12790 #_mapperClass: "NPG_Content_Model_Mapper_Journal" #_formClass: "NPG_Content_Form_Journal" #_name: null #_shortname: null #_frequence: null #_openAccess: null #_launchDate: null #_type: null #_category: null #_paywall: null #_adddate: null #_moddate: null #_lastEditedBy: null #_dirty: false #_lazyLoaded: true #_form: NPG_Content_Form_Journal {#12834 #_attribs: [] #_decorators: array:3 [ "FormElements" => array:2 [ …2] "HtmlTag" => array:2 [ …2] "Form" => array:2 [ …2] ] #_defaultDisplayGroupClass: "Zend_Form_DisplayGroup" #_description: null #_disableLoadDefaultDecorators: false #_displayGroupPrefixPaths: [] #_displayGroups: [] #_elementDecorators: array:1 [ 0 => "Composite" ] #_elementPrefixPaths: array:2 [ 0 => array:3 [ …3] 1 => array:3 [ …3] ] #_elements: array:11 [ "adddate" => Zend_Form_Element_Hidden {#12835 …30} "moddate" => Zend_Form_Element_Hidden {#12831 …30} "last_edited_by" => Zend_Form_Element_Hidden {#12827 …30} "name" => Zend_Form_Element_Text {#12823 …30} "shortname" => Zend_Form_Element_Text {#12819 …30} "frequence" => NPG_Form_Element_JournalFrequence {#12816 …35} "open_access" => Zend_Form_Element_Checkbox {#12812 …34} "paywall" => Zend_Form_Element_Checkbox {#12807 …34} "launch_date" => Zend_Form_Element_Text {#12803 …30} "type" => NPG_Form_Element_JournalType {#12799 …35} "category" => NPG_Form_Element_JournalCategory {#12795 …35} ] #_elementsBelongTo: null #_errorMessages: [] #_errorsExist: false #_errorsForced: false #_formOrder: null #_isArray: false #_legend: null #_loaders: array:2 [ "ELEMENT" => Zend_Loader_PluginLoader {#12837 …4} "DECORATOR" => Zend_Loader_PluginLoader {#12836 …4} ] #_methods: array:4 [ 0 => "delete" 1 => "get" 2 => "post" 3 => "put" ] #_order: array:11 [ "adddate" => null "moddate" => null "last_edited_by" => null "name" => null "shortname" => null "frequence" => null "open_access" => null "paywall" => null "launch_date" => null "type" => null "category" => null ] #_orderUpdated: true #_subFormPrefixPaths: [] #_subForms: [] #_translator: null #_translatorDisabled: false #_view: null #_isRendered: false } #_mapper: null #_id: 14 #_persisted: true #_validate: true #_foreignKeys: [] } #_name: "News & Views" #_pluralName: "News & Views" #_shortname: "nv" #_identifier: "nv" #_tocOrder: 30 #_presentInToc: true #_exportable: true #_adddate: Zend_Date {#12934 -_locale: "en_US" -_fractional: 0 -_precision: 3 -_unixTimestamp: "1343791230" -_timezone: "Asia/Tokyo" -_offset: -32400 -_syncronised: 0 #_dst: true } #_moddate: Zend_Date {#12935 -_locale: "en_US" -_fractional: 0 -_precision: 3 -_unixTimestamp: "1344460508" -_timezone: "Asia/Tokyo" -_offset: -32400 -_syncronised: 0 #_dst: true } #_lastEditedBy: NPG_System_Model_Record_User {#12789 #_mapperClass: "NPG_System_Model_Mapper_User" #_formClass: "NPG_System_Form_User" #_email: null #_firstname: null #_lastname: null #_password: null #_lastLogin: null #_lastFailedLogin: null #_nFailedLogin: 0 #_banned: null #_deleted: null #_adddate: null #_moddate: null #_dirty: false #_lazyLoaded: true #_form: NPG_System_Form_User {#12791 #_attribs: [] #_decorators: array:3 [ "FormElements" => array:2 [ …2] "HtmlTag" => array:2 [ …2] "Form" => array:2 [ …2] ] #_defaultDisplayGroupClass: "Zend_Form_DisplayGroup" #_description: null #_disableLoadDefaultDecorators: false #_displayGroupPrefixPaths: [] #_displayGroups: [] #_elementDecorators: array:1 [ 0 => "Composite" ] #_elementPrefixPaths: array:2 [ 0 => array:3 [ …3] 1 => array:3 [ …3] ] #_elements: array:11 [ "email" => Zend_Form_Element_Text {#12988 …30} "firstname" => Zend_Form_Element_Text {#12992 …30} "lastname" => Zend_Form_Element_Text {#12996 …30} "password" => Zend_Form_Element_Password {#13000 …31} "last_login" => Zend_Form_Element_Text {#13005 …30} "last_failed_login" => Zend_Form_Element_Text {#13010 …30} …5 ] #_elementsBelongTo: null #_errorMessages: [] #_errorsExist: false #_errorsForced: false #_formOrder: null #_isArray: false #_legend: null #_loaders: array:2 [ …2] #_methods: array:4 [ …4] #_order: array:11 [ …11] #_orderUpdated: true #_subFormPrefixPaths: [] #_subForms: [] #_translator: null #_translatorDisabled: false #_view: null #_isRendered: false } #_mapper: null #_id: 1 #_persisted: true #_validate: true #_foreignKeys: [] } #_dirty: true #_lazyLoaded: false #_form: NPG_Content_Form_JournalSection {#12887 #_attribs: [] #_decorators: array:3 [ "FormElements" => array:2 [ …2] "HtmlTag" => array:2 [ …2] "Form" => array:2 [ …2] ] #_defaultDisplayGroupClass: "Zend_Form_DisplayGroup" #_description: null #_disableLoadDefaultDecorators: false #_displayGroupPrefixPaths: [] #_displayGroups: [] #_elementDecorators: array:1 [ 0 => "Composite" ] #_elementPrefixPaths: array:2 [ 0 => array:3 [ …3] 1 => array:3 [ …3] ] #_elements: array:11 [ "adddate" => Zend_Form_Element_Hidden {#12890 …30} "moddate" => Zend_Form_Element_Hidden {#12894 …30} "last_edited_by" => Zend_Form_Element_Hidden {#12898 …30} "journal_id" => Zend_Form_Element_Hidden {#12902 …30} "name" => Zend_Form_Element_Text {#12906 …30} "plural_name" => Zend_Form_Element_Text {#12910 …30} "shortname" => Zend_Form_Element_Text {#12914 …30} "identifier" => Zend_Form_Element_Text {#12918 …30} "toc_order" => Zend_Form_Element_Text {#12922 …30} "present_in_toc" => Zend_Form_Element_Checkbox {#12926 …34} "exportable" => Zend_Form_Element_Checkbox {#12930 …34} ] #_elementsBelongTo: null #_errorMessages: [] #_errorsExist: false #_errorsForced: false #_formOrder: null #_isArray: false #_legend: null #_loaders: array:2 [ "ELEMENT" => Zend_Loader_PluginLoader {#12888 …4} "DECORATOR" => Zend_Loader_PluginLoader {#12889 …4} ] #_methods: array:4 [ 0 => "delete" 1 => "get" 2 => "post" 3 => "put" ] #_order: array:11 [ "adddate" => null "moddate" => null "last_edited_by" => null "journal_id" => null "name" => null "plural_name" => null "shortname" => null "identifier" => null "toc_order" => null "present_in_toc" => null "exportable" => null ] #_orderUpdated: true #_subFormPrefixPaths: [] #_subForms: [] #_translator: null #_translatorDisabled: false #_view: null #_isRendered: false } #_mapper: null #_id: 27 #_persisted: true #_validate: false #_foreignKeys: array:2 [ "journal_id" => "14" "last_edited_by" => "1" ] } 2 => NPG_Content_Model_Record_JournalSection {#12936 #_mapperClass: "NPG_Content_Model_Mapper_JournalSection" #_formClass: "NPG_Content_Form_JournalSection" #_journal: NPG_Content_Model_Record_Journal {#12938 #_mapperClass: "NPG_Content_Model_Mapper_Journal" #_formClass: "NPG_Content_Form_Journal" #_name: null #_shortname: null #_frequence: null #_openAccess: null #_launchDate: null #_type: null #_category: null #_paywall: null #_adddate: null #_moddate: null #_lastEditedBy: null #_dirty: false #_lazyLoaded: true #_form: NPG_Content_Form_Journal {#12982 #_attribs: [] #_decorators: array:3 [ …3] #_defaultDisplayGroupClass: "Zend_Form_DisplayGroup" #_description: null #_disableLoadDefaultDecorators: false #_displayGroupPrefixPaths: [] #_displayGroups: [] #_elementDecorators: array:1 [ …1] #_elementPrefixPaths: array:2 [ …2] #_elements: array:11 [ …11] #_elementsBelongTo: null #_errorMessages: [] #_errorsExist: false #_errorsForced: false #_formOrder: null #_isArray: false #_legend: null #_loaders: array:2 [ …2] #_methods: array:4 [ …4] #_order: array:11 [ …11] #_orderUpdated: true #_subFormPrefixPaths: [] #_subForms: [] #_translator: null #_translatorDisabled: false #_view: null #_isRendered: false } #_mapper: null #_id: 14 #_persisted: true #_validate: true #_foreignKeys: [] } #_name: "Article" #_pluralName: "Articles" #_shortname: "af" #_identifier: "af" #_tocOrder: 45 #_presentInToc: true #_exportable: true #_adddate: Zend_Date {#13082 -_locale: "en_US" -_fractional: 0 -_precision: 3 -_unixTimestamp: "1343791229" -_timezone: "Asia/Tokyo" -_offset: -32400 -_syncronised: 0 #_dst: true } #_moddate: Zend_Date {#13083 -_locale: "en_US" -_fractional: 0 -_precision: 3 -_unixTimestamp: "1698288785" -_timezone: "Asia/Tokyo" -_offset: -32400 -_syncronised: 0 #_dst: true } #_lastEditedBy: NPG_System_Model_Record_User {#12937 #_mapperClass: "NPG_System_Model_Mapper_User" #_formClass: "NPG_System_Form_User" #_email: null #_firstname: null #_lastname: null #_password: null #_lastLogin: null #_lastFailedLogin: null #_nFailedLogin: 0 #_banned: null #_deleted: null #_adddate: null #_moddate: null #_dirty: false #_lazyLoaded: true #_form: NPG_System_Form_User {#12939 #_attribs: [] #_decorators: array:3 [ …3] #_defaultDisplayGroupClass: "Zend_Form_DisplayGroup" #_description: null #_disableLoadDefaultDecorators: false #_displayGroupPrefixPaths: [] #_displayGroups: [] #_elementDecorators: array:1 [ …1] #_elementPrefixPaths: array:2 [ …2] #_elements: array:11 [ …11] #_elementsBelongTo: null #_errorMessages: [] #_errorsExist: false #_errorsForced: false #_formOrder: null #_isArray: false #_legend: null #_loaders: array:2 [ …2] #_methods: array:4 [ …4] #_order: array:11 [ …11] #_orderUpdated: true #_subFormPrefixPaths: [] #_subForms: [] #_translator: null #_translatorDisabled: false #_view: null #_isRendered: false } #_mapper: null #_id: 1 #_persisted: true #_validate: true #_foreignKeys: [] } #_dirty: true #_lazyLoaded: false #_form: NPG_Content_Form_JournalSection {#13035 #_attribs: [] #_decorators: array:3 [ "FormElements" => array:2 [ …2] "HtmlTag" => array:2 [ …2] "Form" => array:2 [ …2] ] #_defaultDisplayGroupClass: "Zend_Form_DisplayGroup" #_description: null #_disableLoadDefaultDecorators: false #_displayGroupPrefixPaths: [] #_displayGroups: [] #_elementDecorators: array:1 [ 0 => "Composite" ] #_elementPrefixPaths: array:2 [ 0 => array:3 [ …3] 1 => array:3 [ …3] ] #_elements: array:11 [ "adddate" => Zend_Form_Element_Hidden {#13038 …30} "moddate" => Zend_Form_Element_Hidden {#13042 …30} "last_edited_by" => Zend_Form_Element_Hidden {#13046 …30} "journal_id" => Zend_Form_Element_Hidden {#13050 …30} "name" => Zend_Form_Element_Text {#13054 …30} "plural_name" => Zend_Form_Element_Text {#13058 …30} "shortname" => Zend_Form_Element_Text {#13062 …30} "identifier" => Zend_Form_Element_Text {#13066 …30} "toc_order" => Zend_Form_Element_Text {#13070 …30} "present_in_toc" => Zend_Form_Element_Checkbox {#13074 …34} "exportable" => Zend_Form_Element_Checkbox {#13078 …34} ] #_elementsBelongTo: null #_errorMessages: [] #_errorsExist: false #_errorsForced: false #_formOrder: null #_isArray: false #_legend: null #_loaders: array:2 [ "ELEMENT" => Zend_Loader_PluginLoader {#13036 …4} "DECORATOR" => Zend_Loader_PluginLoader {#13037 …4} ] #_methods: array:4 [ 0 => "delete" 1 => "get" 2 => "post" 3 => "put" ] #_order: array:11 [ "adddate" => null "moddate" => null "last_edited_by" => null "journal_id" => null "name" => null "plural_name" => null "shortname" => null "identifier" => null "toc_order" => null "present_in_toc" => null "exportable" => null ] #_orderUpdated: true #_subFormPrefixPaths: [] #_subForms: [] #_translator: null #_translatorDisabled: false #_view: null #_isRendered: false } #_mapper: null #_id: 2 #_persisted: true #_validate: false #_foreignKeys: array:2 [ "journal_id" => "14" "last_edited_by" => "1" ] } 21 => NPG_Content_Model_Record_JournalSection {#13084 #_mapperClass: "NPG_Content_Model_Mapper_JournalSection" #_formClass: "NPG_Content_Form_JournalSection" #_journal: NPG_Content_Model_Record_Journal {#13086 #_mapperClass: "NPG_Content_Model_Mapper_Journal" #_formClass: "NPG_Content_Form_Journal" #_name: null #_shortname: null #_frequence: null #_openAccess: null #_launchDate: null #_type: null #_category: null #_paywall: null #_adddate: null #_moddate: null #_lastEditedBy: null #_dirty: false #_lazyLoaded: true #_form: NPG_Content_Form_Journal {#13130 #_attribs: [] #_decorators: array:3 [ …3] #_defaultDisplayGroupClass: "Zend_Form_DisplayGroup" #_description: null #_disableLoadDefaultDecorators: false #_displayGroupPrefixPaths: [] #_displayGroups: [] #_elementDecorators: array:1 [ …1] #_elementPrefixPaths: array:2 [ …2] #_elements: array:11 [ …11] #_elementsBelongTo: null #_errorMessages: [] #_errorsExist: false #_errorsForced: false #_formOrder: null #_isArray: false #_legend: null #_loaders: array:2 [ …2] #_methods: array:4 [ …4] #_order: array:11 [ …11] #_orderUpdated: true #_subFormPrefixPaths: [] #_subForms: [] #_translator: null #_translatorDisabled: false #_view: null #_isRendered: false } #_mapper: null #_id: 14 #_persisted: true #_validate: true #_foreignKeys: [] } #_name: "Letter" #_pluralName: "Letters" #_shortname: "lt" #_identifier: "lt" #_tocOrder: 50 #_presentInToc: true #_exportable: true #_adddate: Zend_Date {#13230 -_locale: "en_US" -_fractional: 0 -_precision: 3 -_unixTimestamp: "1343791229" -_timezone: "Asia/Tokyo" -_offset: -32400 -_syncronised: 0 #_dst: true } #_moddate: Zend_Date {#13231 -_locale: "en_US" -_fractional: 0 -_precision: 3 -_unixTimestamp: "1344467724" -_timezone: "Asia/Tokyo" -_offset: -32400 -_syncronised: 0 #_dst: true } #_lastEditedBy: NPG_System_Model_Record_User {#13085 #_mapperClass: "NPG_System_Model_Mapper_User" #_formClass: "NPG_System_Form_User" #_email: null #_firstname: null #_lastname: null #_password: null #_lastLogin: null #_lastFailedLogin: null #_nFailedLogin: 0 #_banned: null #_deleted: null #_adddate: null #_moddate: null #_dirty: false #_lazyLoaded: true #_form: NPG_System_Form_User {#13087 #_attribs: [] #_decorators: array:3 [ …3] #_defaultDisplayGroupClass: "Zend_Form_DisplayGroup" #_description: null #_disableLoadDefaultDecorators: false #_displayGroupPrefixPaths: [] #_displayGroups: [] #_elementDecorators: array:1 [ …1] #_elementPrefixPaths: array:2 [ …2] #_elements: array:11 [ …11] #_elementsBelongTo: null #_errorMessages: [] #_errorsExist: false #_errorsForced: false #_formOrder: null #_isArray: false #_legend: null #_loaders: array:2 [ …2] #_methods: array:4 [ …4] #_order: array:11 [ …11] #_orderUpdated: true #_subFormPrefixPaths: [] #_subForms: [] #_translator: null #_translatorDisabled: false #_view: null #_isRendered: false } #_mapper: null #_id: 1 #_persisted: true #_validate: true #_foreignKeys: [] } #_dirty: true #_lazyLoaded: false #_form: NPG_Content_Form_JournalSection {#13183 #_attribs: [] #_decorators: array:3 [ "FormElements" => array:2 [ …2] "HtmlTag" => array:2 [ …2] "Form" => array:2 [ …2] ] #_defaultDisplayGroupClass: "Zend_Form_DisplayGroup" #_description: null #_disableLoadDefaultDecorators: false #_displayGroupPrefixPaths: [] #_displayGroups: [] #_elementDecorators: array:1 [ 0 => "Composite" ] #_elementPrefixPaths: array:2 [ 0 => array:3 [ …3] 1 => array:3 [ …3] ] #_elements: array:11 [ "adddate" => Zend_Form_Element_Hidden {#13186 …30} "moddate" => Zend_Form_Element_Hidden {#13190 …30} "last_edited_by" => Zend_Form_Element_Hidden {#13194 …30} "journal_id" => Zend_Form_Element_Hidden {#13198 …30} "name" => Zend_Form_Element_Text {#13202 …30} "plural_name" => Zend_Form_Element_Text {#13206 …30} "shortname" => Zend_Form_Element_Text {#13210 …30} "identifier" => Zend_Form_Element_Text {#13214 …30} "toc_order" => Zend_Form_Element_Text {#13218 …30} "present_in_toc" => Zend_Form_Element_Checkbox {#13222 …34} "exportable" => Zend_Form_Element_Checkbox {#13226 …34} ] #_elementsBelongTo: null #_errorMessages: [] #_errorsExist: false #_errorsForced: false #_formOrder: null #_isArray: false #_legend: null #_loaders: array:2 [ "ELEMENT" => Zend_Loader_PluginLoader {#13184 …4} "DECORATOR" => Zend_Loader_PluginLoader {#13185 …4} ] #_methods: array:4 [ 0 => "delete" 1 => "get" 2 => "post" 3 => "put" ] #_order: array:11 [ "adddate" => null "moddate" => null "last_edited_by" => null "journal_id" => null "name" => null "plural_name" => null "shortname" => null "identifier" => null "toc_order" => null "present_in_toc" => null "exportable" => null ] #_orderUpdated: true #_subFormPrefixPaths: [] #_subForms: [] #_translator: null #_translatorDisabled: false #_view: null #_isRendered: false } #_mapper: null #_id: 21 #_persisted: true #_validate: false #_foreignKeys: array:2 [ "journal_id" => "14" "last_edited_by" => "1" ] } ]
Even when conducting clinical trials to study widely used therapies, researchers must ensure that they disclose the full risks to patients.
doi: 10.1038/500377a
New York pioneers system to protect drinking water from adverse weather events.
doi: 10.1038/500385a
Boost for advocates of open-access research articles.
doi: 10.1038/500386a
Gene for small horns lowers sexual fitness but boosts lifespan.
doi: 10.1038/500387a
Researchers rue the reversal of positive reforms.
doi: 10.1038/500388a
Gaps in oversight of transgenic technologies allow scientists to test the waters for speciality varieties.
doi: 10.1038/500389a
日本の研究者たちが、実験室での卵子と精子の作製に成功したが、これを安全かつ倫理的に利用するにはどうするかが、今後の課題である。
doi: 10.1038/500392a
植物では、草食動物や機械的力などによって損傷を受けると電気シグナルが生じることが分かった。このシグナルは、2個のグルタミン酸受容体様タンパク質によって仲介され、離れた場所で局所的な防御応答を引き起こす。
doi: 10.1038/500404a
星の光度の変動と星の表面での重力加速度の間には相関性があることが観測されている。そのため、こうした加速度を25%を上回る精度で測定することができる。
doi: 10.1038/500405a
改変ヌクレアーゼを使うゲノム編集と光遺伝学という2つの手法を組み合わせることで、標的の遺伝子を光によって調節するための広く使える方法が開発された。
doi: 10.1038/500406a
二酸化バナジウムで2つの絶縁相と1つの伝導相が共存する三重点が観測され、この材料における電子相関の役割を明らかにするのに役立ちそうな物理的性質が明らかになった。
doi: 10.1038/500408a
既存の血管からの新しい血管の形成は、入念に組織化された過程である。解糖による糖代謝が、このような調節に関わっていることが今回明らかになった。
doi: 10.1038/nature12549
生態系ネットワークの構造が種の共存、群集の安定性や擾乱によってどのような影響を受けるのかは、議論が続いている問題である。入れ子構造に相関する性質で見逃されてきたものの1つは、種の個体数らしい。
doi: 10.1038/500411a
動物とその腸内に常在する微生物との間の関係がもたらす広範囲にわたる影響は、だんだんに明らかになってきている。新たな知見によって、こうした関係は種の隔離を維持する障壁まで作り出すことが分かった。
doi: 10.1038/500412a
An analysis of mutations from over 7,000 cancers of diverse origins reveals the diversity of mutational processes underlying the development of cancer; more than 20 distinct mutational signatures are described, some of which are present in many cancer types, notably a signature attributed to the APOBEC family of cytidine deaminases, whereas others are specific to individual tumour types.
doi: 10.1038/nature12477
Upon wounding, plants mount a systemic response resulting in the production of jasmonates, hormones that confer resistance to herbivores; here we identify genes necessary for the electrical activity that leads to jasmonate synthesis far from the wound itself.
doi: 10.1038/nature12478
An analysis of archival data reveals an observational correlation between stellar brightness variations and surface gravity, allowing a determination of surface gravity with a precision of better than 25 per cent for inactive Sun-like stars at main-sequence to giant stages of evolution.
doi: 10.1038/nature12419
The precise location of a solid-state triple point, at which three solid phases coexist in thermal equilibrium, has been determined by controlling the stress and temperature in a nanobeam of vanadium dioxide near its metal–insulator transition.
doi: 10.1038/nature12425
The interplay of spin, energetics and delocalization of the electronic excitations are shown to create a spin blockade of electron–hole recombination in organic photovoltaic cells, resulting in high quantum efficiencies.
doi: 10.1038/nature12339
An annually resolved ice-core record from West Antarctica indicates that warming driven by local insolation resulting from sea-ice decline began in that region about 2,000 years before warming in East Antarctica, reconciling two alternative explanations for deglacial warming in the Southern Hemisphere.
doi: 10.1038/nature12376
Research on the Nile crocodile and five birds shows that limb evolution is shaped by an interplay between natural selection and developmental constraints, the outcome varying between different digits, and between embryos and adults.
doi: 10.1038/nature12336
Cooperation among species tends to result in mutualistic networks with a nested structure, which is thought to increase biodiversity and persistence but may be less stable than unstructured networks: here nested networks are shown to result from a mechanism that maximizes species abundances in mutualistic communities, and the abundance of nested species is found to be directly linked to the resilience of the community.
doi: 10.1038/nature12438
The genome of the asexual rotifer Adineta vaga lacks homologous chromosomes; instead, its allelic regions are rearranged and sometimes found on the same chromosome in a palindromic fashion, a structure reminiscent of the primate Y chromosome and of other mitotic lineages such as cancer cells.
doi: 10.1038/nature12326
Oxytocin is shown to sharpen neuronal network activity by increasing fast-spiking interneuron activity.
doi: 10.1038/nature12330
A human lipid transfer protein (GLTPD1, named here CPTP) is shown to regulate eicosanoid production by mediating the intermembrane transfer of the phosphorylated sphingolipid ceramide-1-phosphate through a non-vesicular transport mechanism elucidated by structural, functional and biological data.
doi: 10.1038/nature12332
Induction of autophagy is coupled to reduction of histone H4 lysine 16 acetylation through downregulation of the histone acetyltransferase hMOF, showing that histone modifications regulate the outcome of autophagy.
doi: 10.1038/nature12313
Here the customizable TALE DNA-binding domain was integrated with the light-sensitive cryptochrome 2 protein and its interacting partner (CIB1) from Arabidopsis thaliana, thereby creating an optogenetic two-hybrid system called light-inducible transcriptional effectors (LITEs); the LITE system establishes a novel mode of optogenetic control of endogenous transcription and epigenetic states.
doi: 10.1038/nature12466
Whole-genome bisulphite sequencing data from diverse human cell and tissue types shows that only about 22% of CpGs change their methylation state across these cell types; most of these CpGs are located at gene regulatory elements, particularly enhancers and transcription-factor-binding sites, and these selected regions with dynamic DNA methylation patterns could help to define putative regulatory elements further.
doi: 10.1038/nature12433
The bacterial RecBCD helicase/nuclease shows broad, and apparently static, heterogeneity in the unwinding rate manifest by individual molecules: here it is shown that transiently halting an enzyme during processive translocation allows for a change, most likely conformational, such that the velocity of the molecule after pausing can fall anywhere within the spectrum of rates seen for a population.
doi: 10.1038/nature12333
Folate receptor-α (FRα) is overexpressed in many cancer cells and is therefore an important therapeutic target: here the X-ray crystal structure of folate-bound FRα is presented, revealing details of the ligand-binding pocket that may be useful in the development of small-molecule inhibitors for anticancer therapy.
doi: 10.1038/nature12327