欧州委員会が推し進める「欧州オープンサイエンスクラウド」は素晴らしい計画であり、停滞させることなく進めなければならない。
Don’t let Europe’s open-science dream drift p.451
Now that the major players have agreed to the giant European Open Science Cloud, it’s time to get the project moving.
doi: 10.1038/546451a
Now that the major players have agreed to the giant European Open Science Cloud, it’s time to get the project moving.
doi: 10.1038/546451a
Donald Trump’s proposed cuts to ShakeAlert puts the west coast at risk.
doi: 10.1038/nature.2017.22162
Future generations will fear, rather than fend for, the global environment.
doi: 10.1038/546452a
The party of France’s recently elected president won an absolute majority in its first general elections, with an agenda that included strong support for research.
doi: 10.1038/549459a
DNA of 234-year-old tree has few mutations, giving weight to idea that plants protect their stem cells.
doi: 10.1038/546460a
Once the world's biggest DNA sequencer for research, BGI is now looking to medical applications to boost profits.
doi: 10.1038/546461
Fossils from ancient hippo ancestor suggest that grass helped the animals to conquer a continent.
doi: 10.1038/nature.2017.22168
Large analyses dredge up 'peripheral' genetic associations that offer little biological insight, researchers say.
doi: 10.1038/nature.2017.22152
Funding agencies announce harsh penalties and stronger policing efforts.
doi: 10.1038/546464a
Jerry Parosが設立したParoscientific社は、巨大地震の前兆となる小さな変化を捉えることができる精密な海底センサー網の作成に長年取り組んできた。
doi: 10.1038/546466a
今回、マウスの網膜にある運動方向選択性神経節細胞と呼ばれるニューロンの活動を測定することによって、眼によって符号化された視覚的運動が、歩行などの体の動きをマッピングする仕組みが説明された。
doi: 10.1038/nature22505
強い力は、原子核の構成要素を結合している。力の基本相互作用とそれらの鏡像の違いが、重イオン衝突で観測されたと考えられていたが、新しいデータはこの見方に異議を唱えている。
doi: 10.1038/nature23086
線毛は、細菌表面にある繊維状構造で、宿主細胞への付着に用いられる。この付着を妨げる小分子によって、マウスで病原性細菌の腸内定着を防げることが、今回分かった。
doi: 10.1038/nature23084
エジプトのネコのミイラや現代のヤマネコに由来する試料を含む、200を超えるさまざまなネコの標本から得られたサンプルのDNA解析によって、ネコの進化と世界的広がりに関する知見が得られた。
doi: 10.1038/546480a
今回、最先端の技術を組み合わせて、極低温原子対の相互作用によって生じる磁気運動を観測できるようになった。これは、複雑な量子挙動のモデルの開発における大きな進歩である。
doi: 10.1038/546481a
ループスは、脳機能障害を生じ得る自己免疫疾患である。今回、ループスのマウスモデルの研究から、インターフェロンタンパク質によって、脳の免疫細胞がニューロン間のシナプス結合を剪定するようになることが分かった。
doi: 10.1038/nature23087
エアロゾルが気候にどの程度の影響を及ぼすかは、極めて不確かである。今回、火山噴火で生じたエアロゾルと相互作用する雲の観測結果から、その影響は、これまで懸念されていたよりずっと小さいことが示された。
doi: 10.1038/546483a
Investigations of an Icelandic volcanic eruption confirm that sulfate aerosols caused a discernible yet transient brightening effect, as predicted, but their effect on the liquid water path was unexpectedly negligible.
doi: 10.1038/nature22974
Global mapping shows that mouse retinal neurons prefer visual motion produced when the animal moves along two behaviourally relevant axes, allowing the encoding of the animal’s every translation and rotation.
doi: 10.1038/nature22818
Exosomes improve the delivery of siRNA to mutant KRAS in the pancreatic tumours and bypass immune clearance better than artificial liposomes, probably owing to enhanced macropinocytocis and presence of CD47 on exosomes, respectively.
doi: 10.1038/nature22341
The structure of human ABCG2 bound to an inhibitory antibody using cryo-electron microscopy, representing the first high-resolution structural data of a human multidrug transporter.
doi: 10.1038/nature22345
When the Universe was just 3 billion years old, half of the most massive galaxies had already ceased star formation, and such a galaxy has now been observed using gravitational lensing, unexpectedly turning out to be a compact, fast-spinning disk galaxy rather than a proto-bulge galaxy.
doi: 10.1038/nature22388
The giant planet KELT-9b has a dayside temperature of about 4,600 K, which is sufficiently high to dissociate molecules and to evaporate its atmosphere, owing to its hot stellar host.
doi: 10.1038/nature22392
The combination of interparticle interactions and a synthetic gauge field leads to chirality in the propagation dynamics of particles in a ladder-like lattice.
doi: 10.1038/nature22811
An improved reference genome for maize, using single-molecule sequencing and high-resolution optical mapping, enables characterization of structural variation and repetitive regions, and identifies lineage expansions of transposable elements that are unique to maize.
doi: 10.1038/nature22971
Both F17-like and type 1 pili promote intestinal colonization in mouse colonic crypts, and the high-affinity mannoside M4284 reduces intestinal colonization of uropathogenic Escherichia coli while simultaneously treating urinary tract infections without disrupting the composition of the gut microbiota.
doi: 10.1038/nature22972
Single-cell RNA sequencing analysis of two- and three-dimensional hepatic differentiation reveals that both systems recapitulate certain transcriptomic features of human hepatogenesis.
doi: 10.1038/nature22796
Abnormal behavioural phenotypes and synapse loss in the brain of lupus-prone mice are prevented by blocking type I interferon signalling, which is further shown to stimulate microglial phagocytosis of neuronal material in the brains of these mice.
doi: 10.1038/nature22821
Histone deacetylase 3 (HDAC3) is required to activate brown adipose tissue enhancers to ensure thermogenic aptitude.
doi: 10.1038/nature22819
BRCA1-associated protein 1 (BAP1) regulates calcium flux in the endoplasmic reticulum to facilitate the execution of apoptosis, unveiling a new facet of the role of BAP1 as an environmental tumour suppressor.
doi: 10.1038/nature22798
PTEN, a known tumour suppressor, inhibits the FXBL2-dependent degradation of IP3R3, an IP3 receptor, thus augmenting IP3R3-mediated calcium release from the endoplasmic reticulum to mitochondria and inducing apoptosis; inhibiting FXBL2 sensitizes PTEN-deficient tumours to photodynamic therapy.
doi: 10.1038/nature22965
The structure of Cpf1, a CRISPR–Cas/RNA-guided nuclease, is presented with a three-stranded RNA–DNA loop after cleavage, providing insight into its working mechanism.
doi: 10.1038/nature22398
