Proposals to improve the international emergency response to disease outbreaks in the wake of the Ebola epidemic should be implemented — but local solutions are the best defence.
doi: 10.1038/522005a
The coming months promise to shed new light on the Solar System’s underworld.
doi: 10.1038/522006b
The public trusts scientists much more than scientists think. But should it?
doi: 10.1038/522006a
Police investigate researchers' role in devastating bacterial epidemic.
doi: 10.1038/nature.2015.17651
Over rum cocktails at the World Conference on Research Integrity, experts discussed what can be learnt from the fallout of a flawed political-science paper.
doi: 10.1038/522014a
Cultural fight over sacred mountain accelerates observatory closures.
doi: 10.1038/522015a
Next-generation timekeepers can only be tested against each other.
doi: 10.1038/522016a
Relief agency sees its mission expanding after leading response to West Africa epidemic.
doi: 10.1038/522018a
生物学にPCR以来の最も大きな変化をもたらすと期待される遺伝子編集技術CRISPRは、倫理・安全面で、早急に考えねばならない問題を抱えている。
doi: 10.1038/522020a
Moderna Therapeutics社は、どのようにしてRNA薬分野のパワープレーヤーへと成長したのだろうか。
doi: 10.1038/522026a
プランクトン藻類の1つと細菌の一種の間で栄養素やシグナル伝達分子が交換されていることが突き止められ、海中の生命ドメイン間には標的を絞って相利共生的な相互作用が生じていることが明らかになった。
doi: 10.1038/nature14530
リンパ管を形成する細胞についての2つの研究によって、前駆細胞が意外な供給原から生じることが分かり、リンパ管構造の起源が予想されていたより多様であることが実証された。
doi: 10.1038/nature14523
腫瘍抑制タンパク質のPTENはほとんどが細胞質に存在し、エンドソーム小胞に結合している。このような局在が、この酵素の特定の脂質に対する活性を調節し、PTENによる細胞増殖の制御に影響していることが分かった。
doi: 10.1038/nature14531
ハッブル宇宙望遠鏡によって得られた画像から、冥王星の小型の衛星群の軌道、形態やサイズに関する新たな知見が得られた。この解析結果は、冥王星を訪れる初めての探査機が行おうとしている調査計画にちょうど間に合った。
doi: 10.1038/522040a
酸素欠乏状態にある乳がん細胞が分泌する酵素のリシルオキシダーゼ（LOX）が骨損傷の誘導に関わっていて、転移に先立ってできた損傷はがん細胞が骨へと広がるのを促進していることが新たな研究によって示された。
doi: 10.1038/nature14529
B中間子と呼ばれる素粒子の極めてまれな崩壊が、CERNの大型ハドロン衝突型加速器（LHC）で観測された。この結果は素粒子物理学の標準模型を超える物理学を垣間見せるものかもしれない。
doi: 10.1038/nature14520
Analyses of the interactions and rotations of Pluto’s four small moons Styx, Nix, Kerberos and Hydra are reported.
doi: 10.1038/nature14469
Trajectory-dependent firing of neurons within the nucleus reuniens of the thalamus–hippocampus circuit predicted subsequent running direction, and disruption of this circuit reduced predictive firing in the hippocampus, suggesting that the thalamus is a key node in the integration of signals during goal-oriented navigation.
doi: 10.1038/nature14396
The lymphatic endothelium is thought to arise entirely from trans-differentiation of the venous endothelium; a new mechanism of lymphatic vessel formation is identified in zebrafish, whereby the lymphatic vessels derive from specialized angioblasts within the floor of the cardinal vein.
doi: 10.1038/nature14425
The lymphatic system is thought to be derived by transdifferentiation of venous endothelium; this study shows that the origin of cardiac lymphatics is in fact more heterogeneous, including both venous and non-venous origins and that lymphangiogenesis occurs in the adult heart following myocardial infarction and can be enhanced to improve heart function.
doi: 10.1038/nature14483
Combined analysis of proton-proton collision data from the Large Hadron Collider at CERN by the CMS and LHCb collaborations leads to the observation of the extremely rare decay of the strange B meson into muons; the result is compatible with the standard model of particle physics, and does not show any signs of new physics, such as supersymmetry.
doi: 10.1038/nature14474
A dense network of GPS observations shows that rapid lake drainage events on the western Greenland Ice Sheet are preceded by period of ice-sheet uplift and/or enhanced basal slip.
doi: 10.1038/nature14480
New anomalocaridid specimens from the Early Ordovician Fezouata Biota of Morocco show well-preserved trunk anatomy, revealing evidence for the evolution of arthropod limbs.
doi: 10.1038/nature14256
Protein sequences preserved in two Quaternary taxa, Macrauchenia and Toxodon, resolve the evolutionary history of South American native ungulates.
doi: 10.1038/nature14249
Isochron burial dating with cosmogenic nuclides 26Al and 10Be shows that the skeleton of the australopithecine individual known as ‘Little Foot’ is around 3.67 million years old, coeval with early Australopithecus from East Africa; a manuport dated to 2.18 million years ago from the Oldowan tool assemblage conforms with the oldest age previously suggested by fauna.
doi: 10.1038/nature14268
Rett syndrome is caused by mutation of the MECP2 gene that codes for a protein that binds methylated DNA; this study reveals that MeCP2 affects the expression of long genes, which often serve neuronal functions.
doi: 10.1038/nature14319
Mouse hair follicles in the skin cycle between growth and regression, while maintaining a pool of stem cells for continued regeneration; here, live imaging is used to show that a combination of niche-induced stem cell apoptosis and epithelial phagocytosis underlies regression, regulating the stem cell pool.
doi: 10.1038/nature14306
Molecular characterization of interactions between a globally distributed marine diatom and its bacterial consortium.
doi: 10.1038/nature14488
Influenza surveillance over 15 cities across 5 provinces in China from October 2013 to July 2014 shows that the virus has diverged into distinct clades, becoming established in chickens and also disseminating to wider geographic regions.
doi: 10.1038/nature14348
Metastasis to the bone of certain breast cancers can be driven by the enzyme lysyl oxidase (LOX) produced by primary tumour cells.
doi: 10.1038/nature14492
Eukaryotic initiation factor 3 (eIF3)—the deregulation of which has been linked with diverse cancers—is shown to bind to and direct the specialized translation of a subset of messenger RNAs, primarily involved in cell proliferation, differentiation and apoptosis, and can exert either translational activation or repression.
doi: 10.1038/nature14267
