The disappearance of a tantalizing LHC signal is disappointing for those who want to build the next big accelerator.
doi: 10.1038/536125b
Rewarding existing nuclear power plants for the value of their low-carbon power makes sense, but the nuclear industry has a lot of work to do if it is survive and thrive in the twenty-first century.
doi: 10.1038/536125a
But the hunt continues for elementary particles beyond the standard model of physics.
doi: 10.1038/nature.2016.20376
Perlan mission will surf stratospheric waves and conduct atmospheric research.
doi: 10.1038/536134a
Researchers in the United States will soon be able to resume creating chimaera-based projects.
doi: 10.1038/nature.2016.20379
The popular technique has limitations that have sparked searches for alternatives.
doi: 10.1038/536136b
As failures to replicate results using the CRISPR alternative stack up, a quiet scientist stands by his claims.
doi: 10.1038/536136a
Life came to ice-free Canadian corridor too late to sustain migrations of Clovis and pre-Clovis people.
doi: 10.1038/536138a
世界の情報ハイウェイが壊滅的な渋滞に陥るのを避けようと、データ通路の修復と拡張の研究が急がれている。
doi: 10.1038/536139a
銀イオンの迅速な輸送を介して電気を通す固体複合材料が報告された。この材料での銀イオンの拡散速度は一部の液体の場合よりも速く、電荷貯蔵デバイスでの応用に有望と考えられている。
doi: 10.1038/536150a
ニューロン間のシナプス間隙をまたぐナノカラムが、神経伝達分子の放出領域と捕捉領域を連結していることが明らかになった。この知見は、シナプスの構造と調節の機構についての情報を与えてくれる。
doi: 10.1038/nature18917
ヒト大脳皮質を作り上げているモジュールを示した信頼性の高い地図が今回、明らかにされた。これは脳の機能と疾患の解明をさらに進めるための出発点となると期待される。
doi: 10.1038/nature18914
血流中のがん細胞が肺に進入するには、肺の内皮細胞障壁を突破しなければならない。がん細胞はこの離れ業に、内皮細胞の細胞死を誘導するシグナルを送ることで成功していることが、今回明らかになった。
doi: 10.1038/nature19465
タンパク質分解を行う複合体であるプロテアソームの研究から、プロテインキナーゼTORC1を介して作用し、プロテアソームの活性を細胞の必要に応じて調整する、進化上保存されてきた経路が明らかになった。
doi: 10.1038/nature18919
肥満した膵臓がん患者では、脂肪細胞と腫瘍を取り囲む炎症性の微小環境の間に多数存在する相互作用が、予後と化学療法後の転帰が平均より悪いことの原因となっていると分かった。
doi: 10.1038/nature19419
An artificial composite of the super-ionic conductor RbAg4I5 and the electronic conductor graphite exhibits extremely fast diffusion of silver ions at the interface between the two materials, generating both silver-excess and silver-deficient sites.
doi: 10.1038/nature19078
Whole-genome sequencing of 264 clones sampled from 12 Escherichia coli populations evolved over 50,000 generations under identical culture conditions is used to characterize the patterns and dynamics of genome evolution over time.
doi: 10.1038/nature18959
A detailed parcellation (map) of the human cerebral cortex has been obtained by integrating multi-modal imaging data, including functional magnetic resonance imaging (fMRI), and the resulting freely available resources will enable detailed comparative studies of the human brain in health, ageing and disease.
doi: 10.1038/nature18933
Bacteria of the SAR11 clade constitute up to one half of all marine microbes and are thought to require oxygen for growth; here, a subgroup of SAR11 bacteria are shown to thrive in ocean oxygen minimum zones and to encode abundant respiratory nitrate reductases.
doi: 10.1038/nature19068
Proteasome abundance is crucial for cell survival, but how cells maintain adequate amounts of proteasome is unclear; an analysis in yeast identifies TORC1 and Mpk1 as central components of a pathway regulating proteasome homeostasis through the coordinated regulation of regulatory particle assembly chaperones and proteasome subunits—this pathway is evolutionarily conserved with mTOR and ERK5 regulating proteasome abundance in mammals.
doi: 10.1038/nature18943
The upper atmosphere above Jupiter’s Great Red Spot—the largest storm in the Solar System—is hundreds of degrees hotter than anywhere else on the planet; the heating must come from below, suggesting coupling between Jupiter’s lower and upper atmospheres, probably the result of upwardly propagating acoustic or gravity waves.
doi: 10.1038/nature18940
To enable two photons to interact, a single atom in an optical resonator is used to build a universal photon–photon quantum gate; this could lead to applications in long-distance quantum communication and scalable quantum computing that require the processing of optical quantum information.
doi: 10.1038/nature18592
Blue energy is a desirable renewable resource, involving the osmotic transport of ions through a membrane from seawater to fresh water; here, nanopores have been created in two-dimensional molybdenum-disulfide membranes, and shown to generate a substantial osmotic power output.
doi: 10.1038/nature18593
By applying a new geotectonic analysis technique to revised global plate reconstructions, rifted margins are shown to feature an initial slow rift phase followed by an abrupt increase of plate divergence prior to breakup.
doi: 10.1038/nature18319
Reconstruction of the evolutionary history of the chromosome 16p11.2 locus and identification of bolA family member 2 (BOLA2) as a gene duplicated exclusively in Homo sapiens.
doi: 10.1038/nature19075
Synaptic vesicle fusion, as evoked by action potentials, is confined to presynaptic protein nanoclusters, which are closely aligned with concentrated postsynaptic receptors and their scaffolding proteins—an organization termed a ‘nanocolumn’.
doi: 10.1038/nature19058
Human and murine tumour cells induce programmed necrosis (necroptosis) of endothelial cells, which promotes tumour cell extravasation and metastasis.
doi: 10.1038/nature19076
Here, the selection of substrates by the protein–RNA complex known as the signal recognition particle (SRP) is investigated in the bacterium Escherichia coli, revealing that the SRP has a strong preference for hydrophobic transmembrane domains of inner membrane proteins.
doi: 10.1038/nature19070
The signal recognition particle (SRP) preferentially binds peptides destined for secretion before peptide-targeting signals are translated through recognition of elements in their mRNA, including non-coding sequences.
doi: 10.1038/nature19309
Structural data on the protein CASTOR1 reveal how the mTORC1 pathway senses intracellular arginine, suggesting a repurposing of an evolutionarily pre-metazoan mechanism.
doi: 10.1038/nature19079
Single-molecule assays show that the recruitment of UvrA and UvrAB to Mfd–RNA polymerase complex formed on a DNA lesion arrests the translocating complex and causes its dissolution.
doi: 10.1038/nature19080
