EU予算協議がようやく合意に達したが、科学予算の詳細がどうなるか、今後の折衝から目を離してはならない。
A deal on the horizon p.147
Leaders have finally thrashed out the European Union budget for the next seven years. But how much money will go to research is yet to be confirmed.
doi: 10.1038/494147a
Leaders have finally thrashed out the European Union budget for the next seven years. But how much money will go to research is yet to be confirmed.
doi: 10.1038/494147a
Stem-cell trials must be made easier, so that treatments can be based on real data.
doi: 10.1038/494147b
Planning for extreme events must incorporate not just infrastructure but societal preparedness.
doi: 10.1038/494148a
US outbreak foxes a leading web-based method for tracking seasonal flu.
doi: 10.1038/494155a
Tools for data-sharing promise to improve chances of connecting mutations with symptoms of rare diseases.
doi: 10.1038/494156a
Scientists already feeling the bite of US budget sequester.
doi: 10.1038/494158a
Leaders propose 13% cut to commission's proposals.
doi: 10.1038/494159a
Synthetic biology delivers combination therapies into an uncertain market.
doi: 10.1038/494160a
Author-pays service cuts down on redundant reviews.
doi: 10.1038/494161a
ハリケーン「サンディ」による被災を契機に、この全米一の大都会を洪水から守ろうと、市当局と科学者が対策を考え始めている。
doi: 10.1038/494162a
テキサス州のバイオ企業が認可されていない幹細胞治療を行い、物議を醸している。
doi: 10.1038/494166a
脳の基底核にある2つの平行経路を含むニューロンは順番に動き出し、次いで停止するというやり方ではなく、同時に働いて複雑な運動課題を完遂することが、実験により明らかになった。
doi: 10.1038/nature11856
ホウ素錯体は、炭化水素モチーフであるアリル基の「活性化イミン」への付加を触媒する。この反応は、リレーに似た過程を経て行われ、合成に有用な化合物の鏡像異性体が片方だけ得られる。
doi: 10.1038/494179a
病原体は、宿主の抗微生物応答を邪魔するために、オートファジーなどのさまざまな機序を進化させてきた。今回、このような機序についての知識を使って、オートファジー誘導性のペプチドが作製された。これは治療に役立つと考えられる。
doi: 10.1038/nature11947
インド洋の海嶺の1つについての詳細な地質学的解析から、地球マントルに見られる組成の変動は、海嶺に沿った海膨の隆起に意外にも重要な役割を持っていることが示唆された。
doi: 10.1038/nature11950
A systematic investigation of high-resolution G-protein-coupled receptor (GPCR) structures uncovers a conserved inter-helical network of non-covalent contacts that defines the GPCR fold, and provides insights into the molecular determinants of different GPCR conformations.
doi: 10.1038/nature11896
Systematic sampling along the Marion Rise of the Southwest Indian Ridge reveals that its crust is discontinuous and thin, indicating that the rise is supported by low-density depleted mantle beneath it.
doi: 10.1038/nature11842
A cell-permeable peptide is constructed that is derived from a region of an essential autophagy protein called beclin 1; the peptide is a potent inducer of autophagy in mammalian cells and in vivo in mice, and is effective in the clearance of several viruses.
doi: 10.1038/nature11866
Three-dimensional simulations of the global evolution of asteroid 4 Vesta under two overlapping planet-scale collisions closely reproduce its observed shape; but expected large areas of olivine-rich rocks and pure diogenites are not observed on the surface, possibly implying that the outer ~100 km is composed mainly of a basaltic crust (eucrites) with ultramafic intrusions (diogenites).
doi: 10.1038/nature11892
The properties of a quantum bit coupled to both a microwave cavity and a phonon mode in a micromechanical resonator suggest that such systems may allow for storage of quantum information in long-lived phonon states and read-out via microwave photons, with applications in quantum information control.
doi: 10.1038/nature11821
A set of small organic molecules catalyse reactions of unsaturated organoboron reagents with imines and carbonyls to produce amines and alcohols in high enantiomeric purity efficiently, speedily and at low cost through sustainable protocols.
doi: 10.1038/nature11844
Model simulations show that in response to insolation changes only, southern westerlies and feedbacks between sea ice, temperature, evaporation and salinity caused vigorous Southern Ocean ventilation and cooler deep ocean during the interglacials before the mid-Brunhes transition, suggesting that this transition may in fact have resulted from a series of individual interglacial responses to various combinations of insolation conditions.
doi: 10.1038/nature11790
X-ray synchrotron microtomography has revealed the three-dimensional vertebral architecture of Ichthyostega, and other crucial and celebrated early tetrapods; a surprising feature is the relationship between the vertebral elements, with the pleurocentra unexpectedly attached to the succeeding intercentrum, suggesting a ‘reverse’ rhachitomous design.
doi: 10.1038/nature11825
A combination of extensive field surveys and realistic experiments involving an amphibian disease system reveals that biodiversity reduces pathogen transmission due to a predictable link between species richness and the ability of communities to support infection.
doi: 10.1038/nature11883
In a cross between two yeast strains, detected loci are found to explain nearly the entire additive contribution to heritable variation for a number of quantitative traits.
doi: 10.1038/nature11867
In mice performing an operant task, increases in neural activity in direct- and indirect-pathway spiny projection neurons (SPNs) are associated with action initiation but not with inactivity, and concurrent activation of SPNs from both pathways in one hemisphere precedes the initiation of contraversive movements.
doi: 10.1038/nature11846
During retinal vascular development there is simultaneous regression of the hyaloid vasculature and formation of the retinal vasculature; here it is demonstrated that regression of developing vasculature is light dependent and acts via the photoreceptor melanopsin.
doi: 10.1038/nature11823
A mouse model of liver damage has identified a population of Lrg5+ liver stem cells that can generate hepatoctyes and bile ducts in vivo.
doi: 10.1038/nature11826
BRAF inhibitors such as vemurafenib have shown promising effects in patients with BRAF-mutant melanomas, but the tumours generally develop resistance; vemurafenib-resistant melanomas are now shown to be drug dependent, and an intermittent dosing schedule can help prevent drug resistance.
doi: 10.1038/nature11814
Biguanides such as metformin, which is the most widely prescribed drug for type-2 diabetes, are shown to antagonize the actions of glucagon by decreasing the levels of cyclic AMP.
doi: 10.1038/nature11808
The graded expression of the transcription factor T-bet in CCR6−RORγt+ innate lymphoid cells is found to be involved in the control of interferon-γ expression, a cytokine that is required to protect the epithelial barrier against Salmonella infections.
doi: 10.1038/nature11813
High-throughput peptide synthesis and mass spectrometry are used to generate a near-complete reference map of the Saccharomyces cerevisiae proteome; two versions of the map (supporting discovery- and hypothesis-driven proteomics) are then applied to a protein-based quantitative trait locus analysis.
doi: 10.1038/nature11835
