未来を描くSFの世界も、過去と切り離しては考えられない。
The historic truth about science fiction from H. G. Wells to Star Trek p.137
Science fiction fights the past as much as it faces the future.
doi: 10.1038/537137b
Science fiction fights the past as much as it faces the future.
doi: 10.1038/537137b
Procedures have rightly been tightened in response to the controversy surrounding surgeon Paolo Macchiarini — but the institute must take care not to restrict its science.
doi: 10.1038/537137a
doi: 10.1038/537138a
NASA must avoid spreading Earth microbes to suspected water in hillside streaks.
doi: 10.1038/537145a
Research begins at the unabashedly international Francis Crick Institute.
doi: 10.1038/nature.2016.20530
Controversial US guidelines attempt to rein in rogue stem-cell clinics.
doi: 10.1038/537148a
Likelihood of stopgap spending measure grows.
doi: 10.1038/537149a
Samples of the cell line do not match its 50-year-old source ― but how the mix-up occurred is a mystery.
doi: 10.1038/nature.2016.20515
並外れて優秀な子どもの長期研究で、21世紀を担う優れた科学者の育成に必要なことが見えてきた。
doi: 10.1038/537152a
触媒研究の進歩が、よりクリーンで持続可能性の高いエネルギー源や化学産業につながる道となる可能性がある。
doi: 10.1038/537156a
オピオイド化合物と同じような鎮痛活性を持つが、副作用がずっと少ない薬剤が開発された。この成果は、さまざまなタイプの薬剤の創薬に有効となる戦略の1つを明らかにしている。
doi: 10.1038/nature19424
カーボンナノチューブの中を通る水流を測定する実験的手法が開発された。この測定によって、流れの摩擦がほとんどなくなり得ることが明らかになり、ナノ流体のコンピューターシミュレーションに難問が投げ掛けられた。
doi: 10.1038/537171a
地球の陸地表面全体に人類が直接及ぼした影響が、全球の衛星写真と地上測量を使って解析され、世界に残されたヒトの「足跡」のスケールと、その1993~2009年における変化が明らかになった。
doi: 10.1038/537172a
若い星とその親に当たる分子雲の間の相互作用についてはよく分かっていない。オリオン座大星雲の高分解能観測によって、こうした相互作用が今回明らかになった。これは星形成に関わりがあると考えられる。
doi: 10.1038/537174a
スプライソソーム複合体はRNA転写物から非コード配列を2段階に分かれた過程により除去する。第1段階の反応が終わった後のスプライソソームの構造から、活性部位の相互作用やこのような非コード領域に進化の過程で課されてきた制限が明らかになった。
doi: 10.1038/nature19422
魚類の鰭骨と陸生生物の指の骨の間には共通点がほとんどないと考えられてきた。しかし今回、ゼブラフィッシュでの研究で、これら2つの構造のパターン形成にhox遺伝子が非常に似た役割を果たしていることが明らかになった。
doi: 10.1038/nature19425
A light-actuated liquid crystal polymer material system precisely manipulates liquid drops through capillary forces, and can be formed into a variety of shapes.
doi: 10.1038/nature19344
Computational docking to the the μ-opioid-receptor identifies PZM21, a novel selective biased agonist that generates substantial affective analgesia in mice without altering respiration or inducing drug reinforcement.
doi: 10.1038/nature19112
The cryo-electron microscopy structure of the rabbit voltage-gated calcium channel Cav1.1 complex at a nominal resolution of 3.6 ångströms.
doi: 10.1038/nature19321
Cryo-EM reveals the configuration of substrate pre-mRNA within the active spliceosome and suggests how remodelling occurs prior to exon ligation.
doi: 10.1038/nature19316
The solution structure of SecB, a molecular chaperone that exhibits strong antifolding activity, in complex with alkaline phosphatase and maltose-binding protein captured in their unfolded states.
doi: 10.1038/nature18965
One-arcsecond-resolution millimetre-wave images enable the surface of the Orion Bar molecular cloud to be resolved, revealing a fragmented ridge of high-density substructures, photoablative gas flows and instabilities that suggest that the cloud edge has been compressed by a high-pressure wave expanding into the molecular cloud, in contrast to predictions from static equilibrium models.
doi: 10.1038/nature18957
The pressure-driven flow rate through individual carbon nanotubes is precisely determined from the hydrodynamics of emerging water jets, revealing unexpectedly large and radius-dependent surface slippage.
doi: 10.1038/nature19315
Two small-molecule iron catalysts are shown to be capable of facilitating the targeted C–H oxidative modification of amino acids and peptides with preservation of α-centre chirality (a challenging synthesis), producing a diverse range of amino acids and peptides.
doi: 10.1038/nature18941
A 1.3-million-year-long climate history from the Lake Malawi basin in eastern Africa displays a trend towards progressively wetter conditions superimposed on strong 100,000-year eccentricity cycles of temperature and rainfall since the Mid-Pleistocene Transition around 900,000 years ago.
doi: 10.1038/nature19065
Hoxa- and Hoxd-deficient zebrafish generated using Crispr/Cas with fate mapping have reduced fin rays and increased endochondral elements, establishing homology between the developmental programs that create fin rays and the wrists and digits of mammals.
doi: 10.1038/nature19322
A selective inhibitor of the kinetoplastid proteasome (GNF6702) is identified that is highly efficacious in vivo, clearing the parasites that cause leishmaniasis, Chagas disease and sleeping sickness from mice, highlighting the possibility of developing a single class of drugs for these neglected diseases.
doi: 10.1038/nature19339
Hypoxia in germinal centres regulates B cell class switching via its effects on mTOR complex 1 and activation-induced cytosine deaminase activity.
doi: 10.1038/nature19334
The long non-coding RNA Morrbid controls myeloid cell lifespan and regulates apoptosis by repressing the adjacent pro-apoptotic Bcl2l11 gene in cis.
doi: 10.1038/nature19346
Recognition of the X chromosome by the dosage compensation complex in Drosophila relies on the sequence and shape of PionX sites.
doi: 10.1038/nature19338
Biochemical reconstitution of a synthetic human kinetochore with 21 protein subunits and centromeric nucleosomal DNA unveils fundamental principles of kinetochore organization and function.
doi: 10.1038/nature19333