Progress in the use of CRISPR–Cas9 for human germline editing highlights some pressing ethical considerations for research on embryos.
doi: 10.1038/549307a
Researchers who worked with Florian Jaeger have filed a complaint with the US government after the university cleared his name.
doi: 10.1038/nature.2017.22620
Errors in past studies could undermine conservation plans.
doi: 10.1038/nature.2017.22626
Data from spacecraft could help determine the age of Saturn's rings and the persistence of its magnetic field.
doi: 10.1038/nature.2017.22619
Controversy over vessel's name may impede oceanographic collaboration.
doi: 10.1038/nature.2017.22621
Modelled on big physics projects, the International Brain Lab will bring together some of the world’s pre-eminent neuroscientists to probe a single behaviour.
doi: 10.1038/549319a
これまで重視されていなかったナノチューブによる細胞間コミュニケーションが、がんや感染の拡大を助けている可能性がある。
doi: 10.1038/549322a
分子を組み立てることができるナノメートルスケールの機械というアイデアは、長い間SFの世界の話であると考えられてきた。今回そうした機械が実際に作られ、有機合成の新しいモデルの先駆けとなる可能性がある。
doi: 10.1038/549336a
MC1Rタンパク質のいくつかのバリアントは、赤毛と関連しており、黒色腫と呼ばれる皮膚がんを発症するリスクを高める。今回、MC1Rに結合するある脂質が、このリスクを減らすための標的をもたらす可能性が明らかになった。
doi: 10.1038/nature23550
有機材料は、電池の電極に用いられる高価な遷移金属酸化物の代替候補であるが、安定性が不十分であることが多い。分子間相互作用を利用したポリマー設計によって、この問題が解決された。
doi: 10.1038/549339a
赤血球骨髄系前駆細胞と呼ばれる、胚の血液細胞前駆体の変異によって、その子孫細胞であるミクログリアと呼ばれる免疫細胞が異常に活性化し、マウスの神経変性につながることが今回分かった。
doi: 10.1038/nature23547
3D印刷は、金属を扱う製造過程に大変革をもたらす可能性があるが、この手法に適合する工業的に有用な合金はほとんどない。今回、3D印刷を全ての金属に広げることができる可能性がある方法が開発された。
doi: 10.1038/549342a
娘細胞が増殖するかどうかが、母細胞から受け継いだ2つの分子的因子の影響を受けることが、ライブ画像化法によって明らかになり、新生細胞のふるまいがどのように事前に決められているかに関する知見が得られた。
doi: 10.1038/nature23549
A rabies virus-based monosynaptic tracing method is used to show that the external globus pallidus plays a critical role in cocaine-induced behavioural plasticity.
doi: 10.1038/nature23888
Neuromedin receptor NMUR1 is specifically expressed by a subpopulation of type 2 innate lymphoid cells and promotes the inflammatory response of these cells in response to allergens, indicating the importance of neuro-immune crosstalk in allergic responses.
doi: 10.1038/nature24029
Analysis based on high-resolution observations from the Hubble Space Telescope shows that the asteroid 288P is a binary main-belt comet, with properties unlike any known binary asteroid.
doi: 10.1038/nature23892
Various fractional quantum Hall phases are observed in a new generation of bilayer-graphene-based van der Waals heterostructures, including an even-denominator state predicted to harbour non-Abelian anyons.
doi: 10.1038/nature23893
Zirconium nanoparticles introduced into aluminium alloy powders control solidification during 3D printing, enabling the production of crack-free materials with strengths comparable to the corresponding wrought material.
doi: 10.1038/nature23894
Electrochemical actuators based on exfoliated and restacked metallic MoS2 nanosheet electrodes can generate mechanical force in electrolyte solution on intercalation and deintercalation of ions.
doi: 10.1038/nature23668
A molecular machine that can be programmed to position a substrate at one of two directing sites on a molecule, which control the stereochemistry of addition to the substrate, demonstrates complexity, precision and function previously only observed in nature.
doi: 10.1038/nature23677
Comparing the whole genome sequence of Apostasia shenzhenica with transcriptome and genome data from five orchid subfamilies permits the reconstruction of an ancestral gene toolkit, providing insight into orchid origins, evolution and diversification.
doi: 10.1038/nature23897
Surface diffusion of AMPA receptors, from extra-synaptic to synaptic sites at the plasma membrane, is essential for full long-term potentiation in hippocampal neurons and for fear conditioning in living mice.
doi: 10.1038/nature23658
Braf V600E expression in resident macrophage progenitors leads to clonal expansion of ERK-activated microglia, which causes synaptic and neuronal loss in the brain and results in lethal neurodegenerative disease in adult mice.
doi: 10.1038/nature23672
A molecular mechanism for the sensitive detection of long and U-turn DNA by cyclic GMP–AMP synthase (cGAS) both in vitro and in human cells.
doi: 10.1038/nature23890
The protein modification palmitoylation increases the ability of variant forms of the melanocortin-1 receptor (MC1R) to induce pigmentation, and this is linked to reduced development of melanomas.
doi: 10.1038/nature23887
Mother cells transmit mitogen-induced CCND1 mRNA and DNA damage-induced p53 protein to newly born daughter cells, where synthesized cyclin D1 and the p53-regulated CDK inhibitor p21 directly compete to decide between proliferation and quiescence.
doi: 10.1038/nature23880
Combining ancestral protein reconstruction with deep mutational scanning to characterize alternative histories in the sequence space around an ancient transcription factor reveals hundreds of alternative protein sequences that use diverse biochemical mechanisms to perform the derived function at least as well as the historical outcome.
doi: 10.1038/nature23902
The cryo-electron microscopy structure of the ten-subunit human transcription factor IIH, revealing the molecular architecture of the TFIIH core complex, the detailed structures of its constituent XPB and XPD ATPases, and how the core and kinase subcomplexes of TFIIH are connected.
doi: 10.1038/nature23903
