人間関係、雇用、健康を損なう病的ギャンブルの問題に、研究者も政府も、もっと関心を向ける必要がある。
Science has a gambling problem p.379
Researchers and government agencies pay too little attention to pathological gambling. This must change.
doi: 10.1038/d41586-018-01051-z
Researchers and government agencies pay too little attention to pathological gambling. This must change.
doi: 10.1038/d41586-018-01051-z
After 12 months in office, Trump’s effects on science have been as bad as feared.
doi: 10.1038/d41586-018-01001-9
A universal flu vaccine is the only serious defence against a future flu pandemic.
doi: 10.1038/d41586-018-01070-w
Chinese scientists create cloned primates that could revolutionize studies of human disease.
doi: 10.1038/d41586-018-01027-z
Research budget could rise to 3.5% of gross domestic product if agreement struck during coalition talks holds.
doi: 10.1038/d41586-018-01026-0
Science agencies poised to resume normal operations after lawmakers agree on stopgap budget measure that expires on 8 February.
doi: 10.1038/d41586-018-01069-3
Report shows increasing international competition, but suggests that United States remains a scientific powerhouse.
doi: 10.1038/d41586-018-00927-4
Few scientists have had access to a thigh bone kept in a French collection for over a decade.
doi: 10.1038/d41586-018-00972-z
アポロ計画の代表成果の1つである「後期重爆撃期」説が批判にさらされており、太陽系形成のシナリオが大きく見直されている。
doi: 10.1038/d41586-018-01074-6
一時は下火となってしまった植物形態学が、ゲノミクスと画像化技術の進歩によって再び注目を集めている。
doi: 10.1038/d41586-018-01075-5
今回、レーザー光によって微小粒子を捉えて動かす手法を用いて、三次元での物体の視覚表示が行われた。この手法には、現行の方法を超える大きな長所がある。
doi: 10.1038/d41586-018-00859-z
老化は、ホルモンが重要な役割を果たす調節された過程である。今回、2つのホルモン補助受容体の結晶構造が明らかになり、加齢に関連する疾患に重点を置いた創薬に有益となる情報が得られた。
doi: 10.1038/d41586-017-09032-4
クエーサーは、宇宙における最も明るい連続的な光源である。今回、これまで検出された中で最も遠いクエーサーが測定され、初期宇宙の進化と構造が詳細に明らかになった。
doi: 10.1038/d41586-018-00818-8
中国の土壌が浸食されやすい地域で、大規模な植林事業が行われている。今回、衛星画像によって、この事業の効果が明らかになり、予想されている植生の減少が、干ばつ期に起こらなかったことが示された。
doi: 10.1038/d41586-018-00996-5
1938年に、絶対零度に近い温度で液体ヘリウム4が摩擦や粘性なしに流れることが、2つの研究によって実証された。この知見は、低温物理に関する理解の大きな進歩につながった。
doi: 10.1038/d41586-018-00417-7
一過性の細胞の接触は、免疫応答を生じさせるのに不可欠であるが、in vivoで測定するのは難しい。今回、標識法によって、細胞間のこうした相互作用を記録する方法が得られた。
doi: 10.1038/d41586-018-00488-6
Speed and gait selection in mice are controlled by glutamatergic excitatory neurons in the cuneiform nucleus and the pedunculopontine nucleus, which act in conjunction to select context-dependent locomotor behaviours.
doi: 10.1038/nature25448
The crystal structure of shed ectodomain of α-klotho bound to the FGFR1c ligand-binding domain and FGF23 unveils the mechanism by which klotho co-receptors promote hormonal FGF signalling.
doi: 10.1038/nature25451
In chromosomally unstable tumour cells, rupture of micronuclei exposes genomic DNA and activates the cGAS–STING cytosolic DNA-sensing pathway, thereby promoting metastasis.
doi: 10.1038/nature25432
Observations of a quasar at redshift 7.54, when the Universe was just five per cent of its current age, suggest that the Universe was significantly neutral at this epoch.
doi: 10.1038/nature25180
Mapping the three-dimensional trajectory of a Neptune-mass exoplanet across the disk of its cool star reveals that its orbit is nearly perpendicular to the stellar equator, implying the existence of a yet-undetected outer companion planet.
doi: 10.1038/nature24677
By periodically modulating the position of degenerate fermions unidirectionally in a three-dimensional optical lattice, antiferromagnetic correlations in this many-body system can be reduced, enhanced or even switched to ferromagnetic correlations.
doi: 10.1038/nature25135
Photophoretic optical trapping of cellulose particles and persistence of vision are used to produce real-space volumetric images that can be viewed from all angles, in geometries unachievable by holograms and light-field technologies.
doi: 10.1038/nature25176
Xenon isotopic anomalies found in modern plume rocks are explained as the result of iodine-to-plutonium fractionations during early, high-pressure episodes of core formation.
doi: 10.1038/nature25446
Interactions between receptors and ligands on immune cells are visualized in vivo and in vitro using an enzyme-tagged ligand that, when cells interact, leaves behind a detectable label on the receptor-expressing cell.
doi: 10.1038/nature25442
Crystal structures of free and ligand-bound β-klotho reveal that it acts as a primary receptor for FGF21, and demonstrate how a sugar-cutting enzyme has evolved to become a receptor for hormones that regulate metabolic processes.
doi: 10.1038/nature25010
The production of haematopoietic stem cells is repressed during early mammalian embryogenesis by an epigenetic mechanism that involves the action of the Polycomb protein EZH1.
doi: 10.1038/nature25435
Mutations in the nucleotidase-encoding gene NT5C2 drive chemotherapy resistance in relapsed acute lymphoid leukaemia but the mutations also lead to a loss-of-fitness phenotype and to collateral drug sensitivity, which could be exploited for therapy.
doi: 10.1038/nature25186
A blood enhancer cluster forms a highly combinatorial system that allows precise control of Myc expression across normal and leukaemic haematopoietic stem-cell hierarchies.
doi: 10.1038/nature25193
Cryo-electron microscopy reveals the structure of the Kaposi’s sarcoma-associated herpesvirus capsid, and experiments with polypeptides that mimic the smallest capsid protein demonstrate the potential for structure-derived insights to help to develop antiviral agents.
doi: 10.1038/nature25438
The X-ray structure of the integral membrane protein isoprenylcysteine carboxyl methyltransferase suggests mechanisms by which it recognizes both water-soluble and membrane-bound reactants to catalyze the methylation of RAS and other CAAX proteins at the membrane-cytosol interface.
doi: 10.1038/nature25439
