哺乳類の体表の模様に関わる遺伝子の解明が進んでいる。
Deciphering the genes that give mammals their stripes and patterns p.5
Researchers spot genes in an African mouse to identify the genetics of developmental patterning.
doi: 10.1038/539005b
Researchers spot genes in an African mouse to identify the genetics of developmental patterning.
doi: 10.1038/539005b
Upheaval in the former superpower is bad for research and the wider world.
doi: 10.1038/539005a
An MP’s dismissive tweet that scientists have ‘no experience of the real world’ highlights a chasm in mutual understanding.
doi: 10.1038/539006a
Antarctic agreement follows years of failed discussions and represents the first major conservation effort in the high seas.
doi: 10.1038/nature.2016.20900
Many biologists are founding their own firms as venture capitalists show increased interest in science.
doi: 10.1038/539014a
DSCOVR’s computer may be suffering from radiation-induced glitches, months after it became the primary sentinel for incoming solar storms.
doi: 10.1038/nature.2016.20880
As gene editing opens doors, plant researchers are hamstrung by the need for better ways to slip their molecular tools into cells.
doi: 10.1038/539016a
Wolbachia-infected mosquitoes will be widely deployed in two South American cities to combat viral infections.
doi: 10.1038/nature.2016.20878
Joshua Gordon says that his focus at the National Institute of Mental Health will be on quick wins, brain circuits and mathematical rigour.
doi: 10.1038/nature.2016.20893
再生可能エネルギーの価格が低下すれば、アフリカの多くの国が、化石燃料エネルギーの力を借りることなく、クリーンなエネルギーのみで未来を築ける可能性がある。
doi: 10.1038/539020a
サルが石を打ち割る様子の観察から、石が割れる際に、鋭い縁を持つ、石器に似た形の石片が偶然できることが分かった。故意に石を割るというこの行動は、意図的な石の加工の進化について疑問を投げ掛けるものだ。
doi: 10.1038/nature19484
染色体の末端部分が短くなると細胞の寿命が制限されるようになる。がん細胞の一部は、テロメアの代替伸長と呼ばれる機構を介してこうした運命を回避している。この機構の分子的詳細が今回明らかにされた。
doi: 10.1038/nature19483
極低温原子気体に多数の波長にわたる音波のカスケードが見つかったことは、量子力学の原理によって支配される流体中の乱流についての我々の理解を進展させると考えられる。
doi: 10.1038/539036a
細胞が分解すべきタンパク質に目印を付けるための、これまで知られていなかった方法が細菌で見つかった。アミノ酸のアルギニンがリン酸化されると、そのタンパク質はプロテアーゼによる分解の標的となるのである。
doi: 10.1038/539038a
ある特定の意味を表す語を発音したときの音は、言語によってさまざまであると一般に考えられている。だが、言語についての大規模な研究から、発音された音と意味の間にある程度の関連が広く見られることが明らかになった。
doi: 10.1038/nature20474
アクシオンと呼ばれる素粒子は、基礎物理学の2つの大きな謎を解決する可能性があることから、探索が続けられている。アクシオンの予想質量が、野心的な研究によって今回計算された。この結果は実験による探索を様変わりさせることになるかもしれない。
doi: 10.1038/539040a
The structure of the bacterial toxin BinAB, which is used to combat mosquito-borne diseases, reveals pH-sensitive switches and carbohydrate-binding modules that may contribute to the larvicidal function of the toxin.
doi: 10.1038/nature19825
In Gram-positive bacteria, arginine phosphorylation by the McsB kinase functions as a general post-translational marker for Clp-mediated proteolysis.
doi: 10.1038/nature20122
Alternative lengthening of telomeres in cancer cells is initiated by a specialized replisome and noncanonical homologous recombination at damaged telomeres, culminating in the synthesis of long tracts of telomere DNA.
doi: 10.1038/nature20099
REXER, a new method that allows long sections of DNA to be inserted or replaced in the genome of the bacterium Escherichia coli, is used to investigate codon replacement schemes for the generation of synthetic genomes.
doi: 10.1038/nature20124
The unusual dark red coloration of Charon’s northern polar cap is shown to be produced from hydrocarbons that are cold-trapped from Pluto’s escaping atmosphere during winter.
doi: 10.1038/nature19340
The mass of the axion, a particle that is central to many dark-matter theories, is calculated via the equation of state of the Universe and the temperature dependence of the so-called topological susceptibility of quantum chromodynamics.
doi: 10.1038/nature20115
The gradual development of a turbulent cascade in a weakly interacting homogeneous Bose gas is observed on application of a periodic driving force.
doi: 10.1038/nature20114
The flavouring, perfume and pharmaceutical industries rely on the selective hydrogenation of α,β-unsaturated aldehydes to generate unsaturated alcohols; here, a new type of highly selective catalyst is described in which platinum nanoparticles are sandwiched between a core and a shell of a metal−organic framework.
doi: 10.1038/nature19763
Deformation experiments on bridgmanite indicate that it may be the main contributor to the shear wave anisotropy observed around several subducting plates.
doi: 10.1038/nature19777
Wild capuchin monkeys in Brazil deliberately break stones, unintentionally producing flakes similar to the ancient sharp-edged flakes characterized as intentionally produced Pliocene–Pleistocene hominin tools, although why they do so remains unclear.
doi: 10.1038/nature20112
The mutually exclusive expression of the Hoxa11 and Hoxa13 genes is required for pentadactyl (five-digit) limbs and is proposed to have contributed to the transition from several digits polydactyl (several-digit) limbs in the earliest tetrapods.
doi: 10.1038/nature19813
Drosophila sechellia, a species closely related to the model species Drosophila melanogaster, bypasses a premature stop codon in neuronal cells to express a functional olfactory receptor protein from an assumed pseudogene template.
doi: 10.1038/nature19824
A study of the early genetic diversity and history of the HIV-1 epidemic in North America through sequencing of eight full-length viral genomes from the 1970s.
doi: 10.1038/nature19827
Single-cell RNA sequencing of bone marrow innate lymphoid cell (ILC) precursors reveals that PD-1 marks a committed ILC progenitor and that ILC2 development requires Bcl11b and IL-25R expression; activated ILCs can also be depleted by a PD-1 antibody.
doi: 10.1038/nature20105
The small-molecule HIF-2α antagonist PT2399 causes tumour regression in animal models of clear cell renal cell carcinoma, but cell lines of this tumour type show unexpectedly variable responses to PT2399.
doi: 10.1038/nature19795
The HIF-2 antagonist PT2399 is tested in mice bearing tumourgrafts derived from human renal cell cancers to demonstrate its efficacy, identify markers of sensitivity and characterize its effects.
doi: 10.1038/nature19796
The structure of the VO subcomplex of yeast V-ATPase, solved by electron cryomicroscopy, reveals a new subunit and suggests a mechanism for the translocation of protons across membranes.
doi: 10.1038/nature19828
