再生可能エネルギーを推進するドイツの勇敢な試みを、支援すべきだ。
Energy crossroads p.137
Everyone should wish Germany well in its great experiment in renewable energy.
doi: 10.1038/496137b
Everyone should wish Germany well in its great experiment in renewable energy.
doi: 10.1038/496137b
Controversy over the results touted by a genetic-ancestry firm has highlighted the need for reform of the United Kingdom’s restrictive libel law.
doi: 10.1038/496137a
A court ruling to remove age limits on access to emergency contraception must prevail.
doi: 10.1038/496138a
Researchers suspect H7N9 virus is in bird markets as human cases rise rapidly.
doi: 10.1038/496145a
Researchers get to grips with effects of heat, drought and storms on carbon release.
doi: 10.1038/496147a
Horses, dogs and even a tiger have received the unproven therapies. Now, drug regulators plan to weigh in.
doi: 10.1038/496148a
US supply stockpile for combating bioterror attacks and pandemics feels the strain of funding cuts.
doi: 10.1038/496149a
As US Supreme Court justices prepare to hear arguments in Myriad Genetics case, observers are debating the impact of the outcome on personal genomics.
doi: 10.1038/496150a
Technique to make tissue transparent offers three-dimensional view of neural networks.
doi: 10.1038/496151a
新たに見つかったコレステロール値を極端に下げる遺伝子変異が、超大型新薬の開発につながるかもしれない。
doi: 10.1038/496152a
ドイツが打ち出した大胆な温室効果ガス排出削減計画の実現には、高い技術的、経済的ハードルをクリアする必要がある。
doi: 10.1038/496156a
哲学者でもあったアルベール・カミュは『人生とは自分が行ったすべての選択の積み重なりだ』と言っている。ヒトとラットで、新しく考案・設計された実験を行った結果、こうした選択における誤りの多くは感覚に起因するもので、認識力によるものではないことが示された。
doi: 10.1038/496172a
らせん導波路を六角形配列したアレイを使って、障害や欠陥を回避しながら一方向に進むロバストな光波が、トポロジカル絶縁体の理論で予想されたとおりに観察された。
doi: 10.1038/496173a
不安は単一の神経回路から生じるものではない。不安は、相反的に働く隣接回路間の相互作用によって作り出され、これらの回路の出力が特定の不安応答を調節している。
doi: 10.1038/nature12087
海洋底堆積物から採取された細胞のゲノム塩基配列の解読から、大量に存在する2種類の古細菌系統について、代謝の詳細が明らかになった。このような微生物は、地球内部深くに埋蔵されているタンパク質の分解に重要な役割を果たしているらしい。
doi: 10.1038/nature12088
テロメラーゼは、染色体末端の完全性を守っているDNA塩基配列を合成する。この酵素複合体の構成成分が共同的に会合していく仕組みのモデルから、その構造と機能に関する手がかりが得られた。
doi: 10.1038/nature12090
土星の大気には、氷でできたその環の潜像が隠れていることから、帯電した少量の水氷が、環の平面中にある供給源から上層大気へと磁力線に沿って輸送されていると考えられる。
doi: 10.1038/496178a
The authors show that photosynthetically derived glucose drives target-of-rapamycin signalling, resulting in transcriptional reprogramming of genes involved in cell cycle regulation.
doi: 10.1038/nature12030
The long-awaited structure of a telomerase holoenzyme, from Tetrahymena, has been obtained by electron microscopy; affinity labelling of subunits and modelling with NMR and crystal structures of various components allowed the identification of the catalytic core and subunit interactions, and the functional role of the subunits in telomerase processivity was enabled by performing the first reconstitution of the holoenzyme in vitro.
doi: 10.1038/nature12062
A pattern of features is detected, superposed on Saturn’s low-latitude infrared glow, that implies the transfer of charged species derived from water (ring ‘rain’) from the ring plane to the ionosphere, ultimately leading to the global modulation of upper atmospheric chemistry.
doi: 10.1038/nature12049
An experimental realization of a photonic topological insulator is reported that consists of helical waveguides arranged in a honeycomb lattice; the helicity provides a symmetry-breaking effect, leading to optical states that are topologically protected against scattering by disorder.
doi: 10.1038/nature12066
By use of a hierarchical Bayesian analysis of instrumental and proxy temperature records, early twenty-first-century summers at high northern latitudes are shown to have been warmer than any since 1400.
doi: 10.1038/nature11969
Topographic analyses and numerical modelling of canyon formation across the Hawaiian island of Kaua‘i show that rivers erode into bedrock more efficiently where precipitation rates are higher.
doi: 10.1038/nature11982
Analysis of an Early Jurassic dinosaur bone bed reveals the rapid early growth stages of sauropodomorph embryos as well as the earliest evidence of in situ organic remains from a terrestrial vertebrate.
doi: 10.1038/nature11978
Miscellaneous crenarchaeotal group (MCG) and marine benthic group-D (MBG-D) are among the most numerous archaea in sea-floor sediments; single-cell genomics reveals that these archaea belong to new branches of the archaeal tree and probably have a role in protein remineralization in anoxic marine sediments.
doi: 10.1038/nature12033
Different subregions of the bed nucleus of the stria terminalis are shown to increase and decrease anxiety in mice, and distinct neural projections arising from a single coordinating brain region modulate different anxiety features.
doi: 10.1038/nature12018
Examination of the bed nucleus of the stria terminalis projections to the ventral tegmental area shows that glutamatergic and GABAergic projections have opposing effects on reward and anxiety.
doi: 10.1038/nature12041
In vivo ‘cellular barcoding’ shows that early haematopoietic progenitors are heterogeneous in the cell types that they produce, and this is partly due to an ‘imprinting’ of fate in progenitors, including for a separate dendritic cell lineage.
doi: 10.1038/nature12013
Salmonella effector proteins trigger host innate immunity through the activation of small Rho GTPases, which, in turn, is sensed by the NOD1/2 signalling pathway.
doi: 10.1038/nature12025
Succinate is identified as a metabolite in innate immune signalling, which leads to enhanced interleukin-1β production during inflammation.
doi: 10.1038/nature11986
The crystal structure of the FimD usher traversed by the tip complex of a type 1 pilus demonstrates the mechanism by which pilus subunits are assembled and translocated during pilus elongation.
doi: 10.1038/nature12007
Several X-ray crystal structures of an H+-driven multidrug and toxic compound extrusion (MATE) transporter from Pyrococcus furiosus are presented, whose complex structure with macrocyclic peptides may help facilitate the discovery of efficient inhibitors of MATE transporters.
doi: 10.1038/nature12014
