米国大統領にはヒラリー・クリントン候補がなるべきだ。
Hillary Clinton will make a fine US president p.289
And not only because she is not Donald Trump.
doi: 10.1038/538289a
And not only because she is not Donald Trump.
doi: 10.1038/538289a
Capuchin monkeys have been observed smashing stones to produce flakes — but why they do so remains a mystery.
doi: 10.1038/538290a
A neuroscience initiative is boosting the number of female invited speakers at meetings. Other disciplines should do the same.
doi: 10.1038/538290b
Two former workers say that they were treated unfairly on the basis of age and disability.
doi: 10.1038/nature.2016.20778
Science policy fades into background for many who back Republican candidate in US presidential race.
doi: 10.1038/538298a
Chairman Lamar Smith has turned once-placid panel into investigative powerhouse.
doi: 10.1038/538300a
Breakthrough raises call for debate over prospect of artificial human eggs.
doi: 10.1038/nature.2016.20817
Uncertain government funding drives effort to beef up private support for research.
doi: 10.1038/nature.2016.20802
Five years in, the US EarthCube programme has struggled to deliver on its promises.
doi: 10.1038/538303a
今年の米国大統領選はこれまでになく予測が難しく、人口統計や技術の変化への対応に専門家も苦労している。
doi: 10.1038/538304a
予測市場の精度は驚くほど高いことがあるが、予測市場がなぜうまく働き、どうして失敗するのか、科学的な解明が始まっている。
doi: 10.1038/538308a
アフリカツメガエル（Xenopus laevis）では3400万年ほど前に全ゲノム重複が起こっており、そのためこの有用なモデル生物のゲノム塩基配列解読は難問となっていた。今回、そうした障害がついに克服されてゲノムが解読された。
doi: 10.1038/538320a
70個の近傍銀河のアーカイブデータが今回調べられ、高エネルギーフレアのX線源が2つ見つかった。これらのフレアの起源は明らかになっておらず、これまで知られていなかった宇宙物理学的現象なのかもしれない。
doi: 10.1038/538321a
熱ショックタンパク質が、エピシャペロームと命名された大型のタンパク質複合体の一部となっていることが今回明らかにされた。エピシャペロームは一部のがん細胞の生存を促進するので、がん治療の新しい標的となるかもしれない。
doi: 10.1038/nature19476
天然物と似た構造を持つ化合物のライブラリー中から選び出された分子が、寄生虫であるマラリア原虫の生活環中の複数の段階を標的とすることが示され、マラリアのマウスモデルでは単回の投与でこの病気が治療できることも分かった。
doi: 10.1038/nature19481
高周波数の光の放射とレーザーによって絶縁体に誘起された電子振動の関連性が立証された。これは現在可能な速度よりも速く動作する電子デバイスを作製する取り組みにおける重要なステップである。
doi: 10.1038/538325a
生きている細胞の画像化によって、ミトコンドリアのDNA複製と分裂には小胞体との接触が必要であることが今回示され、2種類の細胞小器官の間に機能に関わる相互作用が起こっていることが明らかになった。
doi: 10.1038/538326b
Computational methods for the de novo design of conformationally restricted peptides produce exceptionally stable short peptides stabilized by backbone cyclization and/or internal disulfide bonds that are promising starting points for a new generation of peptide-based drugs.
doi: 10.1038/nature19791
The two homoeologous subgenomes in the allotetraploid frog Xenopus laevis evolved asymmetrically; one often retained the ancestral state, whereas the other experienced gene loss, deletion, rearrangement and reduced gene expression.
doi: 10.1038/nature19840
The bicyclic azetidines, a class of potent, well-tolerated antimalarial compounds that is active against multiple stages of the Plasmodium life-cycle, has been discovered following screens against libraries of compounds reminiscent of natural products.
doi: 10.1038/nature19804
Here, a genome-wide CRISPR–Cas9 screen is used to identify the Wnt receptors frizzled as physiologically relevant Clostridium difficile toxin B receptors, providing new therapeutic targets for treating C. difficile infections.
doi: 10.1038/nature19799
A search of archival X-ray data for 70 nearby galaxies yielded two flaring sources in globular clusters or ultracompact dwarf companions of parent elliptical galaxies.
doi: 10.1038/nature19822
Investigations using single-cycle intense optical fields to drive electron motion in bulk silicon dioxide show that the light-induced electric currents extend in frequency up to about 8 petahertz.
doi: 10.1038/nature19821
Scanning tunnelling microscopy is shown to be effective for probing energy transfer in a molecular dimer with submolecular resolution in real space.
doi: 10.1038/nature19765
Analysis of the postseismic deformation of the moment magnitude 8.6 Indian Ocean earthquake in 2012 reveals that the asthenospheric layer must be thin and of low viscosity, constraining the structure of oceanic upper-mantle rheology.
doi: 10.1038/nature19787
Postseismic recordings of the moment magnitude 8.6 Indian Ocean earthquake of 2012, combined with the characteristics of olivine creep, provide constraints on the water content of the asthenosphere.
doi: 10.1038/nature19783
Pancreatic cancer is not caused by a specific series of genetic alterations that occur sequentially but by one, or few, catastrophic events that result in simultaneous oncogenic genetic rearrangements, giving rise to highly aggressive tumours.
doi: 10.1038/nature19823
Projections from the mouse visual cortex to the brainstem accessory optic system promote the adaptive plasticity of the optokinetic reflex, which stabilizes images on the retina when an animal is moving.
doi: 10.1038/nature19818
Allogenic induced pluripotent stem cell-derived cardiomyocytes transplanted directly into infarcted cynomolgus monkey hearts show electrical coupling with host cardiomyocytes improve cardiac contractile function after mild immunosuppression.
doi: 10.1038/nature19815
PLVAP selectively controls the seeding of fetal liver monocyte-derived tissue-resident macrophages, seemingly by interacting with chemotactic and adhesive molecules at the diaphragms of liver sinusoidal endothelium.
doi: 10.1038/nature19814
Chaperomes are dynamic assemblies of proteins that regulate cellular homeostasis but specific cellular stresses remodel chaperome components into a stable chaperome network called the epichaperome, which might offer a new cancer target.
doi: 10.1038/nature19807
The structures of the deubiquitinating enzyme Cezanne alone or in complex with its substrate or product are solved, showing how Cezanne specifically targets Lys11-linked polyubiquitin.
doi: 10.1038/nature19836
The atomic structure of ovine mitochondrial complex I is solved at 3.9 Å resolution, revealing that supernumerary subunits stabilize the complex and providing insight into the molecular basis of its function and regulation.
doi: 10.1038/nature19794
Nicotinic acetylcholine receptors are ligand-gated ion channels that mediate fast chemical neurotransmission; here, the first X-ray crystal structure of a nicotinic receptor is reported, revealing how nicotine stabilizes the receptor in a non-conducting, desensitized conformation.
doi: 10.1038/nature19785
